Aarkstore Enterprise- Pharmacogenomics For Clinical Use And In Drug Development

Table of Contents :

Table of Contents :

1. Overview 8

1.1 Statement of Report 8

1.2 Objectives of this Report 8

1.3 Scope of the Study 9

1.4 Methodology 10

1.5 Executive Summary 11

2. Introduction 17

2.1 Pharmacogenomic Testing Overview 17

2.1.1 Clinical Applications 18

2.1.2 Technologies for Pharmacogenomic Diagnostic Tools 19

2.1.3 Drug and Diagnostic Combinations 22

2.1.4 Economic Impact of Healthcare Costs 23

2.2 Genetic Variation among Individuals 33

2.2.1 Population Genomics 33

2.2.2 SNPs and Haplotypes 33

2.2.3 HapMap 35

2.2.3.1 The International HapMap Project 35

2.2.3.2 HapMap Participants and Funding Sources 36

2.3 Drug Metabolism 37

2.3.1 Adverse Drug Reactions (ADRs) 37

2.3.2 Drug-Test Combinations 39

2.4 Impact of Pharmacogenomics 39

2.4.1 How Will Gene Variation Be Used in Predicting Drug Response? 40

2.4.2 How Will Drug Development and Testing Benefit from Pharmacogenomics? 40

2.4.3 Advantages of Pharmacogenomics 40

2.4.4 The DiagnosticsTherapeutics Fusion 41

2.4.5 Potential Challenges 42

2.4.6 Poor Metabolizer Phenotype Testing 44

2.4.7 Drug Repositioning 45

2.5 Pharmacogenomic Tests 46

2.5.1 CYP2D6 46

2.5.2 CYP2C19 and CYP2C9 49

2.5.3 CYP3A4 and CYP3A5 Genotyping 52

2.5.4 CYP1A2 and CYP2B6 54

2.5.5 NAT2, DPD, and UGT1A1 55

2.6 HercepTest 56

2.7 Drivers of Pharmacogenomic Testing 56

2.8 Pharmacogenomics and Drug Discovery 57

2.8.1 Business Implications of Pharmacogenomics in Drug Discovery 58

2.8.2 Impact of Pharmacogenomics on Drug Sales 59

2.8.3 Pressure to Optimize Drug Discovery Drives Use of Pharmacogenomics 60

3. Pharmacogenomic Testing Market: Size, Growth and Share 61

3.1 Global Pharmacogenomic Testing Markets by Technology Segments 61

3.1.1 Market Structure 61

3.1.2 Market Drivers in the Pharmacogenomic Diagnostics Testing Sector 62

3.1.3 Market Restraints in Pharmacogenomic Diagnostic Testing Segment 62

3.1.4 Principal Market Segments for Genomics Testing 62

3.1.4.1 Diagnostic Testing 62

3.1.4.2 Pharmacogenomic Testing 64

3.1.4.3 SNP Identification 65

3.1.5 Key Players in the Pharmacogenomic Diagnostics Testing Segment 67

3.1.6 Pharmacogenomic Testing Sector Analysis 67

3.2 U.S. Pharmacogenomic Testing Market 68

3.2.1 Market Overview 69

3.2.2 Diagnostic Testing Categories 71

3.3 European Pharmacogenomic Diagnostic Testing Market 71

3.4 Japanese Diagnostic Testing Market 71

4. Pharmacogenomic Disease Markers 74

4.1 SNPs 74

4.1.1 SNP Identification Market 74

4.1.2 Overview of SNP Identification 75

4.1.3 Strategies for SNP Identification 76

4.1.4 Candidate Gene Selection 77

4.1.5 Whole-Genome Linkage Disequilibrium Mapping 77

4.1.6 SNP Databases 78

4.1.7 Computational Tools for SNP Identification 80

4.1.8 SNPbrowser, Applied Biosystems 80

4.1.9 Progeny Suite, Progeny Software, LLC 81

4.1.10 Sentrix Array Matrix, Illumina 81

4.1.11 Third Wave Technologies (a Hologic Company) 81

4.2 Predictive Pharmacogenomics 81

4.2.1 Cancer Testing 81

4.2.2 Breast Cancer 83

4.2.3 Melanoma 86

4.2.4 Colon Cancer 87

4.2.5 Predictive Cancer Testing Market Size 89

4.2.6 Prostate Cancer 89

4.2.7 Lung Cancer 89

For more information please contact :

http://www.aarkstore.com/reports/Pharmacogenomics-for-Clinical-Use-and-in-Drug-Development-13789.html

http://blogs.aarkstore.com/

From:Aarkstore Enterprise

Contact: Neel

Email: press@aarkstore.com

http://www.aarkstore.com

by: Aarkstore Enterprise

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