The orally administered fixed combination tablet of tramadol (centrally-acting opiate) plus paracetamol (acetaminophen; nonopiate, nonsalicylate analgesic) [37.5/325mg] provides effective analgesia in patients with moderate to severe acute pain and those with chronic painful conditions characterised by intermittent exacerbations of pain.Two tramadol/paracetamol 37.5/325mg tablets provided greater relief of dental pain over an 8-hour period than either agent alone, with a faster onset of action than tramadol alone and a longer duration of action than either agent as monotherapy.
In patients with postoperative dental pain, two tramadol/paracetamol tablets (37.5/325mg) provided similar analgesia to hydrocodone/paracetamol 10/650mg over an 8-hour period.The addition of one or two tramadol/paracetamol 37.5/325mg tablets (up to four times daily) for 5 days to existing NSAID or cyclo-oxygenase-2 inhibitor analgesic therapy provided effective pain relief in patients with osteoarthritis flare pain.
Tramadol/paracetamol 37.5/325mg provided similar efficacy to that of codeine/paracetamol 30/300mg in patients with chronic back pain in a 4-week, randomised, double-blind trial (a maximum of 10 tablets or capsules per day of the active drug).