Acquisition Of Hsv During Pregnancy
Genital herpes is the main cause of genital ulcers worldwide; the prevalence of HSV 2 infections in the general population ranges from 10% to 60%
. Most genital herpes is caused by HSV-2, although HSV-1 accounts for about half of new cases in developed countries. The risk of HIV acquisition is three times higher in people with HSV-2.
Neonatal herpes is an uncommon but serious complication of genital herpes. The acquisition of genital herpes during pregnancy has been associated with spontaneous abortion, prematurity, and congenital and neonatal herpes. The frequency of seroconversion, maternal symptoms of the disease, and the timing of its greatest effect on the outcome of pregnancy have not been systematically studied.
Doctors studied 7046 pregnant women whom serologic tests showed to be at risk for HSV infection. Serum samples obtained at the first prenatal visit, at approximately 16 and 24 weeks, and during labor were tested for antibodies to HSV 1 and HSV 2 by the Western blot assay, and the results were correlated with the occurrence of antenatal genital infections.
Women who were initially seronegative for both HSV 1 and HSV 2 had an estimated chance of seroconversion for either virus of 3.7 percent; those who were initially seropositive only for HSV 1 had an estimated chance of HSV 2 seroconversion of 1.7 percent; and those who were initially HSV 2 seropositive had an estimated chance of zero for acquiring HSV-1 infection.
Ninety-four of the women became seropositive for HSV; 34 of the 94 women (36 percent) had symptoms consistent with herpes infection. Among the 60 of the 94 pregnancies for which the time of acquisition of HSV infection was known, 30 percent of the infections occurred in the first trimester, 30 percent in the second, and 40 percent in the third.
HSV seroconversion completed by the time of labor was not associated with an increase in neonatal morbidity or with any cases of congenital herpes infection. However, among the infants born to nine women who acquired genital HSV infection shortly before labor, neonatal HSV infection occurred in four infants, of whom one died.
Two percent or more of susceptible women acquire HSV infection during pregnancy. Acquisition of infection with seroconversion completed before labor does not appear to affect the outcome of pregnancy, but infection acquired near the time of labor is associated with neonatal herpes and perinatal morbidity.
Most genital HSV-2 infections are unrecognised and undiagnosed; infected individuals, even with mild symptoms, shed HSV, and can infect sexual partners. Since clinical diagnosis is neither sensitive nor specific, virological and type-specific serological tests should be used routinely. Antiviral treatment of the infected partners and condom use reduce the risk of sexual transmission of HSV-2.
Yet strangely, herpes cures are among the most difficult dermatological treatments to have success with. Sure, there are antiviral drugs available, which can help, but they take time to process through the digestive tract to have a full systemic effect on herpes. A cure is needed immediately once an outbreak appears. Pills often take time to take effect and are not a cure for herpes virus infections when full blown.
If cures for herpes are not administered, outbreaks can last for 2 to 20 days, depending on the individual. After the sores disappear, a remission period follows. However, the notorious viral shedding may still occur from time to time. Very recent advances in the scientific understanding of medicinal plants suggest a much broader use in the treatment for herpes infections than science thought possible just ten years ago.
Science has identified a significant number of naturally occurring molecules in certain plant species. These include phenols, polyphenols, terpenes (e.g., mono-, di-, tri-), and flavonoids all of which have incredible antiviral action. These molecules are naturally occurring in certain plant extracts and heavily concentrated in our anti-herpes treatments.
As a result, the OutbreakBalm-Rx extracts are very important anti-HSV agents as noted by Dr. Schnaubelt after investigating their antiviral activity. The main pharmacological effects of our anti-herpes treatments are their immunostimulative and antiviral functions. They are devoid of toxicity and negative side effects when used per instructions.
OutbreakBalm-Rx's ability to inactivate the extra-cellular herpes virus at concentration much lower than those in other treatments, and also for its ability to inhibit the cell-to-cell virus diffusion in already infected cells, makes this product unique and far superior to all others in the market for herpes simplex treatment or genital herpes treatment. To learn more, please go to http://www.naturespharma.org.
by: bcured
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