Agmatine - China White Stone Texture - Wall Stone Texture
Clinical significance
Clinical significance
Treatment with exogenous agmatine exerts neuroprotective effects in animal models of ischemia and neurotrauma.
History
The term "agmatine" was coined in 1910 by Albrecht Kossel, the German scientist who first identified the substance in herring sperm.
See also
Agmatine deiminase
References
^ Kossel, Albrecht 1910. ber das Agmatin. Zeitschrift fr Physiologische Chemie 66: 257-261
Jae-Hwan Kim, et al. Agmatine reduces infarct area in a mouse model of transient focal cerebral ischemia and protects cultured neurons from ischemia-like injury. Experimental Neurology. 189 (2004) 122 130
Sa-Hyun Kim. Regulation of subventricular zone stem cell proliferation and differentiation by agmatine. Graduate School, Yonsei University. (2006) article
Central Sensitization: The endogenous NMDA antagonist and NOS inhibitor Agmatine inhibits spinal long term potentiation (G. Wilcox, A. Fiska, F. Haugan, F. Svendsen, L. Rygh, A. Tjolsen and K. Hole. American Pain Society. Published by Elsevier Science. 2004)
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Amino acid metabolism metabolic intermediates
Kcetyl-CoA
lysine
Saccharopine Allysine -Aminoadipic acid -Aminoadipate Glutaryl-CoA Glutaconyl-CoA Crotonyl-CoA -Hydroxybutyryl-CoA
leucine
-Ketoisocaproic acid Isovaleryl-CoA 3-Methylcrotonyl-CoA 3-Methylglutaconyl-CoA HMG-CoA
tryptophanlanine
N'-Formylkynurenine Kynurenine Anthranilic acid 3-Hydroxykynurenine 3-Hydroxyanthranilic acid 2-Amino-3-carboxymuconic semialdehyde 2-Aminomuconic semialdehyde 2-Aminomuconic acid Glutaryl-CoA
G
Gyruvateitrate
glycineerine
3-Phosphoglyceric acid
glycinereatine: Glycocyamine Phosphocreatine Creatinine
Glutamate
-ketoglutarate
histidine
Urocanic acid Imidazol-4-one-5-propionic acid Formiminoglutamic acid Glutamate-1-semialdehyde
proline
1-Pyrroline-5-carboxylic acid
arginine
Ornithine Putrescine Agmatine
other
cysteine+glutamatelutathione: -Glutamylcysteine
Gropionyl-CoA
succinyl-CoA
valine
-Ketoisovaleric acid Isobutyryl-CoA Methacrylyl-CoA 3-Hydroxyisobutyryl-CoA 3-Hydroxyisobutyric acid 2-Methyl-3-oxopropanoic acid
isoleucine
2,3-Dihydroxy-3-methylpentanoic acid 2-Methylbutyryl-CoA Tiglyl-CoA 2-Methylacetoacetyl-CoA
methionine
generation of homocysteine: S-Adenosyl methionine S-Adenosyl-L-homocysteine Homocysteine
conversion to cysteine: Cystathionine alpha-Ketobutyric acid+Cysteine
threonine
-Ketobutyric acid
propionyl-CoA
Methylmalonyl-CoA
Gumarate
phenylalanineyrosine
4-Hydroxyphenylpyruvic acid Homogentisic acid 4-Maleylacetoacetate
Gxaloacetate
see urea cycle
Other
Cysteine metabolism
Cysteine sulfinic acid
see also enzymes, disorders
This biochemistry article is a stub. You can help Wikipedia by expanding it.
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Categories: Amines | Guanidines | Metabolism | Biochemistry stubs
by: gaga
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