Amoxicillin & potassium clavulanate is an antibiotic for infection

Amoxicillin & potassium clavulanate is an antibiotic for infection

Amoxicillin, a penicillin-like antibiotic, in combination with potassium clavulanate is used to treat bacterial infection caused due to susceptible microorganism. Amoxicillin and clavulanate potassium is an antibiotic that comes under a group of drugs called penicillins. It is also known as Co-amoxicillin and is used to fight bacteria in the body and treats many different infections caused by bacteria such as pneumonia, sinusitis, ear infection, bronchitis, urinary tract infection and other skin infection.

Bacteria build protective cell wall around itself which saves it from dying. Co-amoxicillin works by inhibiting the synthesis of bacterial cell wall which at last kills bacteria. Co-amoxicillin belongs to penicillin group and is sold under brand name Augmentin in market. Amoxicillin is usually the drug of choice because it is well absorbed than other -lactam antibiotics. It also treats cystic acne effectively. It is susceptible to degradation by -lactamase-producing bacteria, which are resistant to a broad spectrum of -lactam antibiotics, such as penicillin. Therefore it is combined with potassium clavulanate or clavulanic acid, which is a well known -lactamase inhibitor. Both combinations, Amoxicillin & potassium clavulanate, are helpful as it increases efficiency by reducing its vulnerability to -lactamase resistance. It impedes cross-linkage between linear peptidoglycan polymer chains that make up a major component of the cell walls of both Gram-positive and Gram-negative bacteria.

Alternatively clavulanic acid or clavulanate potassium is a -lactam structurally related to the penicillins, possessing the ability to inactivate a wide variety of -lactamases by blocking the active sites of enzymes. Clavulanate potassium, a beta-lactamase inhibitor is combined with antibiotics of penicillin group to overcome certain types of antibiotic resistance. Thus it is used to overcome resistance in bacteria that secrete beta-lactamase, which otherwise inactivates most penicillins. In other word it is active against the plasmid-mediated -lactamases often responsible for transferred drug resistance to penicillins and cephalosporins. It is produced by the fermentation of Streptomyces clavuligerus. It is generated biosynthetically from amino acid arginine and the sugar glyceraldehyde 3-phosphate.

Amoxicillin and clavulanate potassium tablets are indicated in the treatment lower respiratory infection that is caused due to -lactamase-producing strains of H influenzae and M catarrhalis; otitis media caused by -lactamase-producing strains of H influenzae and M catarrhalis; in sinusitis caused by -lactamase-producing strains of H influenzae and M catarrhalis; in skin infections caused by -lactamase-producing strains of S. aureus, E coli, and Klebsiella spp; and in urinary tract infections (UTI) caused by -lactamase-producing strains of E coli, Klebsiella spp., and Enterobacter spp.

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