Antineoplastic Agent Irinotecans Research Progress

Irinotecan is one of the new drugs listed in the cytotoxic drugs new member camptothecin derivatives

. As early as 1966, substances camptothecin with anti-tumor activity has been extracted from the Chinese plant camptotheca acuminata. But due to its poor water solubility and it is difficult to predict severe toxicity, its further application is limited and the study was interrupted. Until 1985, the progress of molecular biology clarifies the camptothecin's acting mechanism and special target DNA topology isomerase I. The depth study of these findings and clinical pharmacology inspired the design of efficient and good water-soluble climax camptothecin analogues. Irinotecan is one result of these studies.

Irinotecan was developed by the Japanese .In order to clear the value of the solid tumors treatment, a lot of researches are carried on a global scale. The large-scale clinical trials show that irinotecan is an effective drug for the treatment of metastatic colorectal cancer, fluorouracil resistant cases is still valid. At present, the drug has been jointly approved by the United States and the European Union, listed on the over 100 countries around the world. In March 2001, the drug entered into Chinese market.

In vitro, studies have shown that irinotecan and its metabolites with broad-spectrum anti-tumor activity of various tumor cell lines. In vivo studies, intravenous, intraperitoneal and oral administration, the observed anticancer activity of CPT-11 syngeneic mice transplanted tumor, the same broad-spectrum anticancer activity.

In recent years, according to the results of animal experiments and in vitro experiments, the people began to irinotecan for the treatment of other tumors. The study found that compared with the standards program, the use of irinotecan, topotecan in combination with cisplatin to treat non-small cell lung cancer, can significantly prolong the survival period. Similarly, in the comparative study of the standard treatment of small cell lung cancer program, also received the same conclusion. Jointly present, the number of irinotecan with different plant extracts drugs to treat non-small cell lung cancer clinical trials are underway, the results of these studies will help clarify the role of irinotecan in the treatment of lung cancer. In addition, except for the treatment of non-small cell lung cancer, small cell lung cancer, cervical cancer and ovarian cancer, irinotecan other tumors such as breast cancer, malignant glioma and gastric cancer have a certain effect.

And 5-FU, over the years has been the drug of choice for the treatment of advanced colorectal cancer, the efficiency of about 11%. By extending the 5-FU infusion or combined with biochemical modulator can improve the efficacy of treatment failure is still a lack of effective drugs for further treatment. Irinotecan for the semi-synthetic derivative of camptothecin derivatives, it has a unique molecular structure and mechanism of action, determines the unique clinical benefits, does not affect the quality of life, prolong the survival period.

Present, although much research work has been carried out on irinotecan, there are a lot of problems of drug metabolism efficacy and side effects remaining unsolved. They include the irinotecan individuals significant pharmacokinetic differences, irinotecan major metabolites generation and elimination of way in the pathogenesis of late-onset diarrhea, the correlation between resveratrol pharmacokinetic parameters and pharmacodynamic evaluation, and the ways to resolve the side effects and how to avoid the dose increase. They all need further exploration. In short, clear the above mechanism, optimize of dosing regimens and improve tumor response will be the guiding direction for future research.

by: anelwew

POST COMMENT

Do Your Research Before Hiring Any Lettings Agent Search For Good Apartment Moving Company To Shift Your Belongings Safely Do You Want To Know All About Jobs In Mumbai? Top Link Building Strategies For Successful Search Engine Optimisation Airline Jobs Vacancies Keywords Will Grab The Search Engine How To Search For Employees In Mongolia Search Term Popularity On Search Engine Result Page How To Boost Search Engine Optimization With Google Adwords? The Benefits Of Using Research Chemicals Budget Phuket Hotel Search Why Karon Is The Best Location Selecting Among Analytical Research Labs Searching For The Best Acne Treatments