Antiviral Medication For Herpes
Antiviral medications used against herpes viruses work by interfering with viral replication
, effectively slowing the replication rate of the virus and providing a greater opportunity for the immune response to intervene. However, the emergence of drug-resistant strains of HSV is a growing problem and represents a serious concern both in terms of clinical management and of viral ecology.
All drugs in this class depend on the activity of the viral enzyme thymidine kinase to convert the drug sequentially from its prodrug form to monophosphate (with one phosphate group), diphosphate (with two phosphate groups), and finally to the triphosphate (with three phosphate groups) form which interferes with viral DNA replication.
There are several prescription antiviral medications for controlling herpes simplex outbreaks, including aciclovir, valaciclovir, famciclovir, and penciclovir. Acyclovir was the original and prototypical member of this drug class; it is now available in generic brands at a greatly reduced cost. Valaciclovir and famciclovir -- prodrugs of aciclovir and penciclovir, respectively -- have improved solubility in water and better bioavailability when taken orally.
Aciclovir is the recommended antiviral for suppressive therapy for use during the last months of pregnancy to prevent transmission of herpes simplex to the neonate in cases of maternal recurrent herpes. The use of valaciclovir and famciclovir, while potentially improving treatment compliance and efficacy, are still undergoing safety evaluation.
Several studies in humans and mice provide evidence that early treatment with famciclovir soon after the first infection with herpes can significantly lower the chance of future outbreaks of herpes. Early use of famciclovir has been shown to reduce the amount of latent virus in the neural ganglia.
Antiviral medications are also available as topical creams for treating recurrent outbreaks on the lips, although their effectiveness is disputed. Penciclovir cream has a 7-17 hour longer cellular half-life than aciclovir cream, increasing its effectiveness relative to aciclovir when topically applied. In summary, acyclovir is the most popular prescribed cure for herpes viral dispersion.
However, the emergence of aciclovir-resistant virus strains has created the need for the development of new effective antiviral agents. And once again, the genital herpes cure is proving to be more difficult. New anti-herpetic chemical drug compounds have been identified as possible cures for herpes, but they have significant adverse effects when consumed and HSV has again developed drug resistance to these new compounds.
As new chemical drug options are not viable, alternative antiviral herpes cures are being investigated with great interest. Recent scientific studies of medicinal antiviral plant extracts show very encouraging results for a herpes cure, and have sparked a new methodology for treating herpes.
Studies of these antiviral extracts demonstrate that many of these compounds exhibit significant anti-herpetic activity. Several actually inactivate HSV with great effectiveness. These antiviral extracts represent new effective treatment options for therapeutic use as virucidal agents for recurring herpes infections.
OutbreakBalm-Rx is a potent anti-herpes agent vital in the treatment of HSV, which is composed of naturally occurring high intensity antiviral extracts which have a lethal effect against herpes simplex viruses 1 and 2 upon exposure. OutbreakBalm-Rx provides maximum and rapid penetration of antiviral agents into cell membranes without damaging human cells.
The mode of action of OutbreakBalm Rx as an anti-herpes agent is particularly interesting not only in consideration of its ability to inactivate the extra cellular herpes virus at very low concentrations, but also for its ability to inhibit the cell-to-cell virus diffusion in already infected cells, which makes this product one of a kind and superior to all others.
It comes as no surprise that application of this product during prodrome, the tingling before an outbreak, can prevent herpes blisters forming, aborting the pending flare up altogether. Topical application of this antiviral treatment inhibits and kills the herpes virus, making it an important and versatile remedy for home use in the fight against herpes. To learn more, please go to http://www.naturespharma.org.
by: bcured
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