Asbestos Induced Diseases Include Mesothelioma And Lung Cancer

The development of asbestos induced disease can vary depending on several critical factors

. One interesting study that examines this issue is called, Asbestos-induced phosphorylation of epidermal growth factor receptor is linked to c-fos and apoptosis by Christine L. Zanella, Cynthia R. Timblin, Andrew Cummins, Michael Jung, Jonathan Goldberg, Rachel Raabe, Thomas R. Tritton, and Brooke T. Mossman - Am J Physiol Lung Cell Mol Physiol 277 - Vol. 277, Issue 4, L684-L693, October 1999. Here is an excerpt: We examined the mechanisms of interaction of crocidolite asbestos fibers with the epidermal growth factor (EGF) receptor (EGFR) and the role of the EGFR-extracellular signal-regulated kinase (ERK) signaling pathway in early-response protooncogene (c-fos/c-jun) expression and apoptosis induced by asbestos in rat pleural mesothelial (RPM) cells. Asbestos fibers, but not the nonfibrous analog riebeckite, abolished binding of EGF to the EGFR. This was not due to a direct interaction of fibers with ligand, inasmuch as binding studies using fibers and EGF in the absence of membranes showed that EGF did not adsorb to the surface of asbestos fibers. Exposure of RPM cells to asbestos caused a greater than twofold increase in steady-state message and protein levels of EGFR (P < 0.05).

The tyrphostin AG-1478, which inhibits the tyrosine kinase activity of the EGFR, but not the tyrphostin A-10, which does not affect EGFR activity, significantly ameliorated asbestos-induced increases in mRNA levels of c-fos but not of c-jun. Pretreatment of RPM cells with AG-1478 significantly reduced apoptosis in cells exposed to asbestos. Our findings suggest that asbestos-induced binding to EGFR initiates signaling pathways responsible for increased expression of the protooncogene c-fos and the development of apoptosis. The ability to block asbestos-induced elevations in c-fos mRNA levels and apoptosis by small-molecule inhibitors of EGFR phosphorylation may have therapeutic implications in asbestos-related diseases.

Another study is called, Alveolar macrophage stimulation of lung fibroblast growth in asbestos-induced pulmonary fibrosis. By I. Lemaire, H. Beaudoin, S. Mass, and C. Grondin - Am J Pathol. 1986 February; 122(2): 205211. Here is an excerpt: Abstract - Asbestotic lesions are characterized by macrophagic accumulation, fibroblast proliferation, and collagen deposition. To evaluate the potential involvement of alveolar macrophages in the subsequent fibrogenic reaction, the authors studied the effects of macrophages from normal and asbestos-treated rats upon lung fibroblast proliferation in vitro. Culture supernatants from bronchoalveolar (BAL) cells (99% macrophages) of normal rats stimulated lung fibroblast DNA synthesis and growth in a dose-dependent manner. Fibroblast growth factor (FGF) release by alveolar macrophages (AMs) was rapid (within 1 hour of incubation) and dependent on the number of AMs in culture. Moreover, culture supernatants from BAL cells of animals exposed to asbestos (single intratracheal injection) stimulated fibroblast proliferation to a greater degree than culture supernatants from BAL cells of control animals. Enhanced FGF production occurred 1 week after asbestos instillation and persisted up to 24 weeks.

This change was accompanied in the early stages (1-4 weeks) by an increase in the total number of BAL cells which returned to control values by 12 weeks. Differential analysis of BAL cell populations showed a transient infiltration of neutrophils in the bronchoalveolar compartment followed by a significant accumulation of macrophages which persisted up to 1 month. Furthermore, lungs of asbestos-treated animals showed evidence of pathologic alterations characterized by fibroblast proliferation and collagen deposition. This study demonstrates that increased production of fibroblast growth factor by alveolar macrophages in vitro coincides with the development of asbestos-induced fibrosis. Prolonged stimulation of FGF release may contribute to excessive fibroblast proliferation and fibrosis.

If you found any of these excerpts, please read them in their entirety. We all owe a debt of gratitude to these researchers.

by: Mont Wrobleski

POST COMMENT

High Concentrations Of Amosite Asbestos Fibers Can Cause Disease Nephrogenic Systemic Fibrosis Disease Caused By Gadolinium Mri Dye Discover - Treat Premature Early Ejaculation Using Butea Superba Herbal Capsules Useful Info - Role Of Testosterone In Male Health - How To Boost Testosterone Naturally Why It Is Important To Eat Healthy Try Good Home Cures for Hemorrhoids - Get Rid of Hemorrhoids Permanently SOAP &quot;A DO-IT-YOURSELF VACCINE&quot; Highly Rated - The Best Way To Enlarge Your Penis Over The Winter Do Not Let Hemorrhoids Affect You Socially - Treat Them Permanently Alternative Alcoholism Treatment Including Herbs For Alcoholism Treat Your Hemorrhoids Permanently - Learn the Correct Steps Here Can A Healthy 40 Year Old Woman Conceive? - Tips for Increasing Your Chances of Getting Pregnant Even if You Are in Your 40s Are You Tired of Hemorrhoids and Looking For Relief? Eliminate Hemorrhoids Using This System