Caspases, GAT antibodies and their role in cancer research

Antibody suppliers provide a wide range of reagents for use in cancer research

. One of the most common areas of study is apoptosis, or programmed cell death, a complicated cascade involving many individual proteins and pathways. We at Novus Biologicals have an extensive apoptosis antibody catalogue, with over 8000 proteins products. Proteins targeted include Apaf-1; Bcl-2; Bax; FAS and the caspases.

Apoptosis is essential to normal development and maintenance of the organism. Cells have a finite life span, and there is a constant program of cellular replacement and removal which is very finely controlled. Apoptosis also deals with cells considered a threat to the organism, such as those infected by viruses, those which have fulfilled an immune system function and those with DNA mutations or which identify themselves as cancer cells. Apoptosis is an important part of cancer research, since resistance to programmed cell death is known to be a key element in the survival of tumour cells.

Malignancies develop in response to delayed or inhibited apoptosis. Cells will then live longer, and often grow faster, than normal cells, allowing tumours to develop. This is often due to defects in the cell signalling pathways, which can also make tumour cells more resistant to chemotherapy drugs. Thus a large amount of research is done in overcoming resistance to apoptosis, or in stimulating apoptotic pathways to encourage programmed cell death of cancer cells.

The caspases belong to the cysteine protease enzyme family, and play an essential role in apoptosis. They form three groups: initiator, effector and cytokine processor caspases, which when activated initiate a complex enzyme cascade. Disruption of this mechanism is a key factor in many cancers.

Recently, we announced an exciting new development to our antibody database, becoming the sole distributor for the SDIX Genome Antibody Technology range. A revolutionary new method of producing highly targeted immunoglobulins, it includes a wide range of apoptosis reagents, including BCL-2, BAX and caspase antibodies

Caspases, GAT antibodies and their role in cancer research

By: Sam Desilwa

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