Chemotactic and Haptotactic Properties of Mesothelioma

When STAV serum-free conditioned medium was separated by using fast protein liquid

chromatography Superose 6 gel filtration, two motility-inducing protein peaks were detected. The first peak contained proteins with molecular weight > 220,000 that had both chemotactic and haptotactic properties, while the second peak contained material with apparent molecular weights of approximately 67,000 that had chemotactic and chemokinetic (random motility) but not haptotactic properties. Analysis of the Mr 67,000 material indicated that it was a heat-sensitive and trypsin-digestible protein. The production of both soluble and insoluble extracellular matrix components by human mesothelioma cells and the motile response to these molecules as well as the production of a Mr 67,000 autocrine motility factor-like substance may be important for the highly invasive motile behavior of this tumor." Another interesting study is called, "Complementary value of five carcinoma markers for the diagnosis of malignant mesothelioma, adenocarcinoma metastasis, and reactive mesothelium in serous effusions" by Mick Delahaye C.T. (I.A.C.), Frieda van der Ham, Theo H. van der Kwast M.D., Ph.D. - Diagnostic Cytopathology Volume 17, Issue 2, pages 115120, August 1997. Here is an excerpt: "Abstract - Cytological slides of serous fluids of 41 malignant mesotheliomas, 88 metastatic adenocarcinomas, and 25 reactive effusions were immunostained with the antibodies anti-CEA, MOC-31, Leu-M1, Ber-EP4, and B72.3. Most mesotheliomas and all reactive fluids failed to stain with these antibodies. The sensitivity of the five markers to detect carcinoma cells differed remarkably. Especially MOC-31, Ber-EP4, and B72.3 stained with a high number of carcinoma cases and the complementary value of Ber-EP4 and B72.3 to immunostain carcinoma cells was impressive: 94% of the metastatic adenocarcinoma cases reacted with Ber-EP4 or B72.3 in contrast to 1 of 41 malignant mesotheliomas." Diagn. Cytopathol. 17:115120, 1997

Chemotactic and Haptotactic Properties of Mesothelioma

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