China, The World's First Successful Cultivation Of A Large Mammal Inbred

Human inbreeding deformity and the race will lead to a recession

, but the pig breeding but it can provide excellent human biological experiment "instruments" and to cultivate a pig organs for human transplant foundation.

After 20 years of painstaking efforts, Chinese scientists in the southwestern province of Yunnan has successfully bred pigs for 20 generations in the same nest mother or brother and sister pigs born after mating between pure pig.

This is the 20th generation of the world's first large mammal inbred. Using advanced micro-satellite genetic testing showed that their genetic homogeneity has been reached or exceeded 98.6%.

Responsible for the cultivation of inbred pig Professor Yunnan Agricultural University, Yang Zhi-8, disclosed to reporters in 2004 that inbred pig has entered the 21st generation, a generation is a smooth one-year continuous development.

Recognized by the international genetics community, an animal strain as it has been mating with a full sibling or child up to 20 generations or more generations, and in the 20th generation and subsequent generations can be traced back to common ancestors, to qualify as a inbred. ? Chinese-American scientist, executive director of the International Council of Laboratory Animal Science Dr. Liu Yinong that China cultivated inbred pigs with high-generation, high purity heterozygosity amazing treasure of mankind, it will provide solutions to human health and diseases of the technology platform.

As the pig in anatomy, physiology and metabolism is very similar with the human body, is highly desirable biomedical experimental animals. The genes highly homozygous inbred pig like physics in precision instruments, and analytically pure reagents in chemical reactions, as for biomedical and life sciences research to provide the high sensitivity, specificity and reproducibility Biomedical experimental material.

Nearly a century, the United States, Britain and other countries, scientists have conducted more than 200 inbred pig large-scale experiments are due to severe early generations of inbreeding depression and repeated failures. According to the International Institute of Chinese Academy of Medical Sciences online information retrieval, the world no other countries have pig continuous record of ten generations of inbreeding.

As a result, the international life science community will be large-scale cultivation of mammalian inbred closed as science, that is not inbred in the success of large mammals.

Chinese scientists have rewritten the conclusion. In 1980, Yunnan Agricultural University, Professor Zeng Yangzhi Xishuangbanna in Yunnan, he and his colleagues in a remote cottage and found a nest of closed foster the ideal of inbred parents and piglets, on this basis to begin the cultivation of inbred experiment.

Professor Zeng Yangzhi introduction, development and research of inbred pigs, he used different from the U.S. and British scientists design and a series of important technical measures by the early generations of inbreeding depression can affect the survival of future generations of subculture, every generation insists on full sibling or parent-child mating and offspring rigorous selection and elimination, that makes a smooth inbred pig breeding, and has overcome the phenomenon of inbreeding depression, the current survival rate of nearly 80% of the breed.

Currently, the world's first inbred pig "family" there are nearly 900 members, divided into 18 sub-lines. Reporter at the northern outskirts of Kunming, Yunnan, Yunnan Banna mini pig inbred Laboratory Yuan Zhongchang that inbred pigs compared with normal pigs, size too small, whether they are in the pork, neck and the Long and hard bristle head upright, "wild boar", but also a long, lean, black pigs, the middle of a long white nose, and head with white spots ... ... black and white pigs, each with genetic markers.

Especially for biomedical experiments also the world's smallest pig in the family. A half years old miniature pigs weighing less than 30 kg, while the five-month general pig weight 90 kg or more when you can.

Scientists are attempting to genetically modified pig organs transplanted people. Engaged in domestic and international long-term immunological study of xenotransplantation, Sichuan University Professor Ping Li that the inbred Banna pigs could become the best human organ xenotransplantation donor.

Ping Li and Professor Zeng Yangzhi cooperation in human and pig liver function, drug metabolism in the comparative test. The results show that inbred Banna pigs and humans closer to some of the indicators. Moreover, homozygous inbred high, almost no individual differences, human xenotransplantation once successful, can provide a standardized donor organs.

Currently, the National Natural Science Fund "863 Program" funded by the Yunnan Banna mini pig inbred Laboratory is stepping up to pig to human xenotransplantation basic research. Yang-Zhi Zeng said the study estimated that there will be five years after the breakthrough, when transplanted into the body after solving the immune rejection and related technologies, inbred pig organ is expected to migrate to the body.

by: gaga

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