Cisplatin Is The Major Mesothelioma Chemotherapy Drugs That Face Severe Shortages

Mesothelioma patients on certain types of chemotherapy drugs may have easier access

to their treatment in the wake of an executive order from President Obama. Mesothelioma is a cancer associated with exposure to asbestos. There are more than 2500 people are diagnosed with mesothelioma. The mesothelioma chemotherapy drugs cisplatin is a major drugs. Cisplatin, in combination with pemetrexed (Alimta) is the FDA approved first line treatment for malignant pleural mesothelioma. However, these drugs are in equally short supply. According to the FDA, so far this year the number of drugs in short supply rose to 200 from 178 in 2010. President Barack Obama is calling on the Food and Drug Administration (FDA) to take action to combat shortages of certain critical medications.

Cisplatin is the major mesothelioma chemotherapy drugs that face severe shortages. Cisplatin (Platinol,Cis-diammin-odichloroplatinum dichloridle,platistil,Neo-plain.) is one of commonly used chemical drugs for cancer treatment and have higher efficacy. The inorganic drug of the metal complexes has been a new anticancer drug of chemical therapy, since cisplatin was used in clinic as an anticancer drug. Cisplatin is a cell cycle non-specific drugs. It has cytotoxicity. it can inhibit cancer cell DNA replication. The drug is reportedly in short supply in part because of its popularity, not only for mesothelioma but also for other. It is also applied to the treatment of ovarian cancer, prostate cancer, testicular cancer, lung cancer, nasopharyngeal cancer, esophageal cancer, malignant lymphoma, head and neck squamous cell carcinoma, thyroid cancer and osteosarcoma, etc. in clinic. The latest decree will be issued by President Barack Obama. The Act provides companies to give more advance notice if they plan to stop producing a drug like cisplatin and calls on the FDA to step up its inspection and approval of new drug manufacturing plants. The Obama administration calls the executive order a first step toward addressing the drug shortages.

Because the patents for cisplatin have expired and it is now available in a generic form, Bristol-Myers Squibb has stopped making the brand-name version of the drug. cisplatin has become popular drugs. The inorganic drug of the metal complexes has been a new anticancer drug of chemical therapy, since cisplatin was used in clinic as an anticancer drug. At the same time, the makers of the drug most often paired with cisplatin for treating mesothelioma have gotten a boost from regulators in Europe.

by: zhaowei

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