Common sense: smoking affected by the efficacy of common drugs - efficacy, smoking - the pharmaceuti

Common sense: smoking affected by the efficacy of common drugs - efficacy

, smoking - the pharmaceuti

Smoking is harmful to health can be described as well known, but the impact of smoking on the efficacy of the people but know little about. Research that affect the efficacy of smoking, there are two main reasons: First, smoking, peripheral vasoconstriction and blood pressure, resulting in reduced drug absorption. Second, the harmful ingredients in cigarettes, such as nicotine, tobacco tar, etc., may play a role in drugs to the liver enzyme involved in drug metabolism and activity increase in the number increased to accelerate the in vivo metabolism and discharge, reduced blood Traditional Chinese medicine Effective concentration of compounds. According to an American scientist survey, smokers within half an hour after taking the drug active ingredients get into the blood of only 1.2% to 1.8%; not smokers are up to 21% ~ 24%. Studies show that smoking affected by common drugs of the following:

Cimetidine and ranitidine smoking can affect the acid-suppressing drugs cimetidine and ranitidine in effect, is not conducive to the healing of peptic ulcer, smokers stop taking acid-suppressing drugs , the ulcer recurrence rate was also high.

Vitamin C Swedish physician Andre? Carl experiments, revealed the substances in tobacco there is a Vitamin C have a strong destructive. It has been calculated that smoking can vitamin C content in the blood than the normal 30% decline.

Lidocaine because smoking accelerates the excretion of lidocaine, the use of lidocaine for anesthesia dental extraction, the smokers of anesthesia sent forth, the high incidence of tooth extraction pain .

Insulin experiments show that subcutaneous injection of insulin absorption after smoking an average reduction of 13%, while the first 30 minutes after smoking decreased the most, up to 31%. This affected the extent of insulin absorption and smoking around the time of consistent vasoconstriction, indicating the impact of smoking on insulin absorption and blood vessels caused by smoking has a direct relationship.

Antidepressant smoking causes Abbey for Lin, imipramine and other drugs to reduce the concentration in the blood, thereby reducing the efficacy of antidepressant drugs.

Heparin heparin shorter half-life in vivo in smokers, higher clearance rate.

Oral contraceptives smoking can increase the damage of oral contraceptives on the cardiovascular, more than 35 years of age, daily smoking of more than 15 people, of greater danger. U.S. scientists believe that smoking while serving contraceptives and myocardial infarction mortality rate is 11.7 times the non-smokers. Thus, smoking can promote oral contraceptives and the occurrence and development of myocardial infarction. Therefore, in the United States produced estrogen oral contraceptives are all stated in the instructions on the medication should stop smoking, or smoke should use other contraceptive methods.

Aminophylline smoking asthma patients taking theophylline, the medication significantly speed up the excretion, the duration of drug effect was significantly reduced.

Propranolol propranolol smoking will reduce the concentration in the blood and to increase its clearance rate, thus affecting the efficacy of propranolol. This impact is particularly true of patients with angina pectoris.

Chlordiazepoxide chlordiazepoxide and stability and the stability of smoking can calm, stability and weakens, the greater the efficacy of smoking the worse.

In short, the impact of smoking on the efficacy can not be ignored. I would like to remind smokers, regardless of your body is healthy now, and for your loved ones around, and their long-term health, should promote a scientific way of life, quit all bad habits, courage, and tobacco bye.

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