Detailed In Situ Analysis Offers Better Control, Consistency

In situ monitoring of suspension and emulsions in chemical

, petrochemical and pharmaceutical research and manufacturing typically involves measuring turbidity. But for systems where particle size, shape and concentration change simultaneously, turbidity may not be enough. Advanced inline technology can help scientists and engineers understand how a particle system evolves over time. This leads to better process control and more uniform, consistent results.

[Columbia, MD] April 30, 2010 METTLER TOLEDO recently released a new white paper entitled "Advance Beyond Turbidity: Selecting Appropriate Technology for In Situ Monitoring and Control of Complex Particle and Droplet Systems." The technical review details significant advantages in product quality and yield gained when using advanced inline monitoring technology that measures more than turbidity alone.

"Advance Beyond Turbidity" details how accurate, real-time assessment of particle and droplet size, shape, and count can help improve crystallization (bigger, more uniform crystals), suspension flocculation (better solid-liquid separation and filtration), emulsion (more stable droplet distribution) and fermentation (more accurate cell count and cell dimension for batch repeatability). Better crystallization, suspension flocculation, emulsion and fermentation promote more efficient separation and/or removal of solid particles and liquid droplets in suspension. Overall, production efficiency is improved, costs are reduced, and more uniform, higher quality results are obtained.

Two leading-edge technologies that can provide detailed analysis of particle dimension, shape and number while solutions are in the manufacturing process are METTLER TOLEDO Focused Beam Reflectance Measurement (FBRM) and Particle Video Microscopy (PVM).

FBRM, applied inline, allows for easy interpretation of complex particle systems to gauge process efficiency parameters, such as batch endpoint or filtration rates, or product quality parameters, such as bulk density, flowability or bioavailability.In-process PVM imaging can provide unparalleled understanding of how particles behave in situ. And, as "Advance Beyond Turbidity" shows, detailed in situ monitoring often achieves a much higher degree of accuracy than testing samples that have been separated from their primary manufacturing environment.

To learn more about how choosing the right measurement beyond turbidity can help you optimize, troubleshoot and control complex crystallization, filtration, emulsion, flocculation, milling and suspension operations in your own research and manufacturing processes, download the full white paper free at http://www.mt.com/global/en/home/supportive_content/White_Papers.turbidity.oneColEd.html

Detailed In Situ Analysis Offers Better Control, Consistency

By: Marie-Louise

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