Effects And Side Effects Of Docetaxel

Docetaxel is a kind of clear viscous liquid which show light yellow or yellow color

. It can be used for the failure of advanced election chemotherapy or metastatic non-small cell lung cancer. Unless it belongs to clinical contraindications, the initial treatment should include the anti-cancer drugs. Docetaxel is suitable for the failure of advanced cisplatin-based chemotherapy or metastatic non-small cell lung cancer treatment.

Docetaxel is one of the taxol anticancer drugs. Currently the indications which are proved are breast cancer and non-small cell lung cancer. Their drug mechanism of the microtubule network necessary to interfere with cellular mitosis and interphase cell function split the sky anti-tumor effect. Docetaxel combined with the free tubulin and promote tubulin assembly into stable microtubules while inhibiting their depolymerization, resulting in loss of normal function of microtubules in the generation and microtubule fixed, thus inhibiting cell mitosis. The combination of docetaxel with microtubule does not change the number of strands. This is different with the current clinical application of most of the spindle toxic drugs.

The side effects of docetaxel as follows: in the event of overdose, the patient should be moved to a special care unit and close monitoring of vital organs. Docetaxel is excessive, there is no antidote available. It can be expected to excessive complications, including neutropenia, abnormal skin reactions and feelings. In patients with abnormal liver function and the patients with high-dose treatment, prior platinum drug therapy, or patients with non-small cell lung cancer, if docetaxel dose and irinotecan reaches to 100mg/m2, the incidence of treatment-related deaths will increase.

Docetaxel can only be used for intravenous infusion. All patients must receive oral glucocorticoids before the advanced docetaxel treatment, such as the dexamethasone. It should be taken the day before the docetaxel infusion. It is 16mg every day. And the time should be insisting for at least three days in order to prevent allergic reactions and body fluids retention. The recommended dose of docetaxel is 70-75mg/m2 with intravenous infusion for one hour. It is once every three weeks. According to the calculation of the medication amount of patients, we can use a syringe to draw the required dose and dilute it to 5% glucose injection or 0.9% sdium chloride injection. It needs to be shaking gently and mixed. The concentration could not be larger than 0.74mg/m1.Source:http://www.cospcn.com

by: anelwew

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