Fusion Antibody Sequencing Services

Fusion Antibodies, a trusted CRO, delivers quick and reliable results of Antibody sequencing with unprecedented professionalism

. In addition to our services, we offer tailor-made options that meet your specific research and derivative requirements. Our unmatched strength and expansive knowledge base in this highly skilled area of research helps accelerate your discovery and validation process. Our pioneering services have garnered us the position of a recognized leader in Monoclonal Antibody Sequencing. We provide for deriving a sequence from any antibody producing cell line. From a select few revered names in the business of protein sequencing, we are one of the companies to have also sequenced dead hybridomal cells. For more than 8 years, we have delivered more than 500 antibody sequences for a variety of species including mouse, rat, bovine, human guinea pig, hamster, rabbits and human antibody secreting EBV cell lines. For any given kind of application, you can rest assured of our antibody sequencing for quality, consistency and accurate results.

In the field of molecular biological research, the use of antibody sequencing is for determining the existence of antigen binding residues of an antibody, and the nature of such antigen binding residues in an antibody. Monoclonal antibodies have become an important base in understanding and deploying research in biochemistry, molecular biology, and medicine. Monoclonal antibodies (mAb or moAb) are structurally identical monospecific antibodies. A specific type of B-lymphocytes produces these antibodies, which are all clones generated from a single parent cell. This method is deployed as it makes possible for synthesizing monoclonal antibodies, which specifically bind to a given substance almost any substance for detecting or purifying that substance. From the several antibody sequencing methods, protein sequencing method like Edman degradation, MS, HPLC/MS, etc. are more commonly used for deriving results in antibody sequencing. Antibody sequencing can be accomplished using several methods adopted worldwide, many of which are exorbitantly expensive. Alternatively, DNA sequencing is a relatively, cheaper technology for application in antibody sequencing.

Monoclonal Antibodies are required in various academic, medical and commercial applications, especially clinical research. Several diagnostic tests used for determining small amounts of drugs, toxins or hormones, e.g. monoclonal antibodies to human chorionic gonadotropin (HCG) are used in pregnancy test kits require the presence of antibodies. Another more known diagnostic, which uses antibodies, is the diagnosis of AIDS by the ELISA test. Monoclonal Antibodies are also extensively used in the radioimmunodetection and radioimmunotherapy of cancer amongst which, certain new methods can even target only the cell membranes of cancerous cells. In November 1997, the FDA approved Ritoxin, a new cancer drug based on monoclonal antibody technology. The problem of organ rejection in patients, who have had organ transplants, has seen successful treatments developed using Monoclonal Antibodies called as OKT3, which is an antibody to the T3 antigen produced by T cells of the human immune mechanism. A strain of single pathogen such as Neisseria gonorrhoeae have been successfully classified using Monoclonal Antibodies Sequencing. Quite a few traditionally considered "untreatable" viral diseases have found solutions developed using Monoclonal Antibodies Sequencing. At the pace at which current clinical research is leaping ahead, several research specialists hold the opinion that antibody sequencing could be an important tool in the race to defeat HIV virus, and cure AIDS.

by: Paul Kerr

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