. A non-invasive method for isolating or detecting nucleic acid molecules from an
epidermal sample of a psoriatic lesion of a human subject, comprising: a) applying an adhesive kinesio tape to the psoriatic lesion of the subject in a manner sufficientto isolate an epidermal sample adhering to the adhesive kinesio tape, wherein the epidermal sample comprises nucleic acid molecules; b) detecting expression of the nucleic acid molecules in the epidermal sample by determining a Ct value before and aftertreatment; c) detecting expression of the nucleic acid molecule by detecting a difference in a Ct value before and after treatment, wherein a Ct value is a difference in the number of amplification cycles required to reach a thresholdsignal level between the nucleic acid molecule and a control nucleic acid molecule.