How Diabetic Patients Get Affected By HDL
How Diabetic Patients Get Affected By HDL
HDL or High-Density Lipoprotein is the smallest of the five major groups of lipoproteins. It helps in the transportation of lipids, including cholesterol and triglycerides, through the bloodstream. It is sometimes called good cholesterol because it prevents the arteries from getting clogged, reduces the production of damaging chemicals and repairs damage to the vessel lining. It removes cholesterol from the arteries and transports it back to the liver. High levels of HDL are usually associated with reduced risk of heart diseases.
However, according to a study conducted by the University of Pittsburgh, Graduate School of Public Health, elevated levels of HDL can be harmful for women suffering form Type 1 Diabetes. The study was conducted on 658 volunteers, including both men and women. The participants included patients who were diagnosed with Type 1 Diabetes between 1950 and 1980.
Effects of HDL on Diabetic Patients
The researchers found that the incidence of heart diseases increased substantially in diabetic women with very high HDL levels (over 80mg/dL). However, the study revealed that both male and female participants with very low HDL levels (below 47.5 mg/dL) also faced a higher risk of heart disease. The researchers are further analyzing the relationship between HDL levels and cardiovascular disease.
Another study conducted by at the Medical School of Hannover and the University Hospital Zurich revealed that the vessel-protecting action of HDL gets reduced in Type 2 Diabetics. The researchers compared the metabolic syndrome and the vessel-protecting action of HDL of 33 Type 2 Diabetics with that of 10 healthy adults. The researchers found that the protective function of HDL was considerably impaired in the diabetic sample.
Also, studies suggest that HDL in diabetes patients obstructs arterial dilation by Nitric Oxide. The HDL in diabetics causes this effect because it gets associated with Myristic acid (a 14-Carbon saturated fatty acid). The association results in the deleterious effect.
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