How To Perform Tablet Dissolution For Sample Preparation

Sample preparation typically involves grinding the samples (taking care that this

itself does not generate heat) and placing them in the flasks containing a suitable solvent. Pharmaceutical tablet sonicator kits with specially designed flask racks and a sonication optimizer dissolve solid dosage forms up to 16 times faster than conventional sample preparation systems. The flasks are then placed in the specially designed sonication racks. The 3-gallon kit has a capacity of 15, 100-mL flasks in a single rack and the larger 6-gallon kit holds up to 24, 100-mL flasks in two racks. Ultrasonic energy penetrates the flask walls to dissolve the samples.

A sample preparation in an ultrasonic bath with a poorly optimized design and inadequate power can lead to reduced recovery of API from pharmaceutical tablets. The rapid tablet dissolution excellent active pharmaceutical ingredient recovery is further supported because the ultrasonic bath design eliminates sonication dead spots and maximizes the ultrasonic power, with operation at 320 and 415 watts respectively with energy transmitted into the bath by 42 kHz ultrasonic transducers. The high ultrasonic power assures maximum recovery of API, critical for HPLC assay methods including dose content uniformity testing. Along with minimizing heat buildup the sonicator kit design minimizes transducer burn marks and flask etching. Other kit components include a timer, a drain to facilitate changing the bath, and a cover to protect the bath when not in use.

After use, the flasks themselves should be rinsed and thoroughly cleaned in an ultrasonic cleaner, rinsed again with distilled or DI water to avoid spotting, dried and inspected for chips or cracks. They then can be used for further tests.

by: Dr. Robert Sandor

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