Irinotecan Treats Advanced Alveolar Cell Carcinoma
Alveolar cell carcinoma is a subtype of adenocarcinoma
. It is easy for female to get this disease and the disease has slow development. It also has low rate of EGFR mutations. Early detection and surgical treatment will have good prognosis. The clinical presentation is different from the other lungs. It is easy to misdiagnosis and it has been at advanced stage after diagnosis. In recent years, pharmaceutical raw materials irinotecan and cisplatin show superior efficacy and tolerable dosage in the treatment of non-small cell lung cancer. However, due to the unique acting mechanism of irinotecan, it not only has drug efficacy but also makes a series of adverse reactions. In particular for delayed diarrhea and acute cholinergic syndrome, they should arouse particular concerns.
The irinotecan chemotherapy has heavier irritation on vascular. Patients with multiple chemotherapy, phlebitis comparison in order to avoid the superficial vein puncture failure patients caused by psychological resistance, avoid drug extravasation and superficial phlebitis, mobilization of patients with deep vein catheterization. When irinotecan infusion, should be especially careful, to strengthen the ward visits, always observe the infusion process is successful, and observe whether the infusion at the swelling and heat pain, to prevent drug leakage. For people have the phlebitis, they can use potato chips, hirudoid coated with good alternating effect.
Application 5 - HT 3 receptor antagonists (ondansetron) were routinely before chemotherapy, the patient had no significant vomiting, mild nausea or loss of appetite. These patients have asked the water, and promote the exclusion of the body of toxic substances. Encourage patients to eat and gentle, liquid, light, highly nutritious, easily digestible food rich in vitamins. Avoid cold, spicy, fried, greasy foods, accompanied by heart to ease, reduce anxiety, nausea, poor appetite, the symptoms are mitigated.
Alveolar cell carcinoma of nodular and diffuse categories in the form of X-ray, the latter form is similar to pneumonia, the clinical manifestations of cough, sticky sputum difficult to expectorate. Late more patients with respiratory difficulties, some mild dyspnea. Patients with symptoms have heavier worries about tolerance and chemotherapy.
Irinotecan as a topoisomerase 1 inhibitor, it shows an advantage in the treatment of non-small cell lung cancer. Alveolar cell carcinoma as a special type of adenocarcinoma, the application of the Iraqi legislature irinotecan combined with cisplatin chemotherapy also achieved good effect. But with other programs, irinotecan united cisplatin has significant toxicity. Adverse reactions, including acute acetyl cholinergic syndrome, delayed diarrhea, neutropenia, and gastrointestinal reactions.
If the delayed diarrhea and neutropenia psychosis have improper handling, it not only affects the course of chemotherapy, but even threatens the lives of patients. With the psychological care for patients, care on delayed diarrhea, neutrophil cells disease and acute respiratory distress, the adverse reactions are improved. The tolerance of chemotherapy increases and chemotherapy adaptiveness is enhanced. Thus it can make the successful completion of chemotherapy. It will set continuous confidence in treatment and achieve satisfactory results.Source:http://www.cospcn.com
by: anelwew
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