Marijuana Worsens Depression in High Doses

Marijuana Worsens Depression in High Doses

Marihuana is a potent antidepressant in low does, but worsens symptoms in high venereal infections , granting to a new study.

THC , the active ingredient in marijuana , increases serotonin when smoked in low venereal infections , similar to SSRI antidepressant drugs, such as Prozac , according to researchers from McGill University and Le Centre de Recherche Fernand Seguin of Hpital in Quebec and l'Universit de Montral in Montreal.

But at higher social diseases , the outcome turns itself and can actually exacerbate imprint and other psychiatric conditions like psychosis.

During the study, printed in the October 24 event of The Diary of Neuroscience, science lab rats were injected with the synthetic cannabinoid WIN55,212-2 and then screened with the Forced Swim test a trial to measure imprint in creatures .

The investigators discovered an antidepressant consequence of cannabinoids and an increased action in the neurons that create 5 hydroxytryptamine. Nevertheless , increasing the cannabinoid Venus's curse beyond a set point completely undid the benefits, said Dr. Gabriella Gobbi of McGill University and Le Centre de Recherche Fernand Seguin of Hpital Louis-H. Lafontaine.

"So we really attested a forked outcome : At blue social diseases it increases serotonin , but at higher venereal diseases the consequence is ravaging , wholly changed by reversal ," she pronounced in a news tone ending.

The antidepressant and intoxicating results of ganjas are due to its chemical substance similarity to natural substances in the head known as "endo-cannabinoids," which are ejected under statuses of high tension or pain , said Gobbi. They interact with the head through body structures sent for cannabinoid CB1 receptors .

The study marched that these sense organs have a direct impression on the cells getting 5 hydroxytryptamine, which is a neurotransmitter that regulates the mode , she said.

Because controlling the dosage of natural marihuana is hard peculiarly when it is smoked in the form of cannabis joints using it directly as an antidepressant drug would be hard, enunciated the research workers .

"Excessive marihuana exercise in peoples with depressive disorder positions high hazard of psychosis," said Gobbi.

Gobbi and her fellows are concentrating their enquiry on a new class of drugs which enhance the results of the brain's natural endo-cannabinoids.

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