Mechanism Of Docetaxel And Capecitabine In Treatment Of Breast Cancer

Docetaxel is a new generation of artificial semi-synthetic anti-tumor drugs

. Now it is used for the treatment of a variety of solid tumors. It is through the promotion of microtubule dimer assembly into microtubules, preventing the poly process of leaving the microtubule stabilization and blocking cells in G2 and M phase to inhibit cancer cell proliferation and mitosis.

The pharmacological effects of docetaxel than paclitaxel in the intracellular concentration of 3 times higher than paclitaxel, and a long residence time in the cell, the microtubule affinity is two times that of paclitaxel. Accelerator as a microtubule stabilizer and assembly activity 2 times greater than paclitaxel; as a microtubule depolymerization inhibitor activity is two times larger than paclitaxel. In the anti-tumor activity in vitro tests have confirmed the anti-tumor activity of docetaxel is 1.3 to 12 times that of paclitaxel. Clinical studies have shown that docetaxel compared with paclitaxel for anthracycline-resistant breast cancer, a higher efficiency. Docetaxel is the most effective drug in the second-line treatment in so far anthracycline-resistant breast cancer. Its no obvious cross-resistance with cisplatin, etoposide, fluorouracil, paclitaxel, and its concentration in the cells three times higher than paclitaxel, and a long residence time in the cell.

The main adverse reactions of docetaxel, myelosuppression: neutropenia was the most common; allergic reaction: flushing, with or without erythema, with itching of chest tightness, back pain, dyspnea, drug fever or chills; skin erythema reaction manifests itself, mainly seen in the hands, feet, may also occur in the local rash of the arms, face and chest; fluid retention slip; may be nausea, vomiting or diarrhea and other gastrointestinal reactions. Other adverse reactions include hair loss, asthenia, mucositis, arthralgia and muscle pain, low blood pressure and injection site reactions.

Studies have shown that metastatic breast cancer, docetaxel monotherapy in first line failure rate is 23% to 65%. It is significantly better than the other drugs for pharmaceutical raw materials suppliers. Evidence based medicine docetaxel monotherapy can prolong survival in patients with breast cancer.

Capecitabine was unique within the tumor selective activation pathway, the prototype absorption through the gastrointestinal tract after oral administration, into a unique three-step activation mechanism, and finally reach the tumor tissue after play converted to 5-FU cytotoxicity, the role of cells in S phase, activation of the thymidylate phosphorylase enzyme, its content of breast tissue was significantly higher than in normal tissues, TP activity was lower in normal tissues, compared with 5-FU anti-cancer effect is enhanced toxicity reduction. And on the previously received 5-FU treated cases are still valid. Single-agent second-line treatment of MBC 15.0% to 34.2% and major adverse events were hand-foot syndrome, nausea and vomiting.

Docetaxel and xeloda have a synergistic effect in treatment of advanced breast cancer. Its mechanism is that both of the two drugs are effective in the treatment of breast cancer. But they have different mechanisms of action and the main side effects have no crosses. Docetaxel can mediate tumor within TP activity increases to synergies with xeloda.Source:http://www.cospcn.com

by: anelwew

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