The Tigers open with Mississippi State on the road in a series that they have lost ten straight
. Conference USA play begins the following week with yet another road trip to East Carolina. UTEP will have revenge on the mind September 25th as the Miners were one of Memphis's two wins last year. Four of their first six games are on the road and two of their home games late in the season are against conference favorite Houston and Tennessee. Yet another 2-10 season is in store for Memphis.