Monoclonal Antibodies: 2010 - Market Research Report On Aarkstore Enterprise

Introduction

Introduction

Across the branded prescription pharmaceutical market monoclonal antibodies (MAbs) are forecast to be the strongest performing molecule type, delivering a forecast six year compound annual growth rate of 9.5% over 2009-15, outpacing the growth rates of small molecules, therapeutic proteins and vaccines. As a result, there is a strong correlation between a strong MAbs portfolio and overall company

Features and benefits

Strategic dynamics within the sector are broken down by product, company, geography, therapy area, technology type and target.

The outlook for the sector is compared with other sectors of the pharmaceutical industry: small molecules, therapeutic proteins and vaccines.

The impact of biosimilars on future MAb sales growth is evaluated and compared with small molecule brand sales following genericization

Highlights

While Datamonitor believes biosimilar MAbs will make it onto the major markets, the rate of sales erosion of such a biosimilar MAb will be far less than that experienced by a small molecule upon generic entry.

Your key questions answered

Assess the outlook for the monoclonal antibodies sector through to 2015

Evaluate the impact of monoclonal antibody on company performances across the PharmaVitae universe

Appraise the technological developments being made in the sector and see where monoclonal antibody pipelines are being focussed

Table of Contents :

ABOUT DATAMONITOR HEALTHCARE 2

About the PharmaVitae team 2

Chapter 1 About this Sector Report 3

PharmaVitae Explorer database 3

Chapter structure 3

Data sourcing 4

Chapter 2 Executive Summary 5

Key findings 5

Introduction to the PharmaVitae company universe 7

The prescription pharmaceutical market to 2015 9

The MAb market will deliver the largest and fastest sales growth across the industry 15

The MAb sector will remain the fastest growing across the pharmaceutical industry 22

Historical market analysis 23

Forecast market analysis 26

Chapter 3 MAb Technology Overview 40

Key findings 40

Introduction 41

Monoclonal antibodies as therapeutic agents 43

Evolution of MAbs 47

Antibody drug conjugates an alternative combination therapy 55

Bispecific antibodies is now the time for commercial success? 57

Trifunctional antibodies successful innovation in a niche indication 58

Ablynxs nanobodies 59

GSKs acquisition of Domantis gives it ownership of DAbs will the leading Big Pharma player in inhalable drug delivery echo this into the antibody market? 60

Systematic naming of MAbs 61

The MAb timelinetechnology evolution 61

Chapter 4 Market Analysis 67

Key findings 67

Introduction 68

MAb market product analysis, 200315 72

MAb market company analysis, 200315 88

MAb market therapy area analysis, 200315 96

MAb market geographic analysis, 200315 105

MAb market technology analysis, 200315 110

MAb market target analysis, 200315 116

Chapter 5 Pipeline Analysis 121

Key findings 121

Introduction 122

MAb pipeline overview 123

Company pipeline analysis 132

Technology pipeline analysis 141

Therapy area pipeline analysis 145

Target pipeline analysis 148

Chapter 6 Key Products 157

Introduction 157

Oncology 158

Immunology & inflammation 171

Central nervous system 183

Infectious diseases 187

Musculoskeletal 191

Other 193

Chapter 7 Appendix 195

References 195

Abbreviations 197

Exchange rates 198

About Datamonitor 199

Datamonitor consulting 199

Disclaimer 201

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