Neuroectodermal Tumors Treatment In India At Mumbai And Delhi At Low Cost.

Neuroectodermal Tumors

Neuroectodermal Tumors

Overview

What causes a PNET?

Researchers have not been able to find an identifiable cause or risk factors for PNET. There doesn't appear to be a genetic predisposition, meaning the disease does not seem to run in families.

What are the symptoms of a PNET?

The symptoms of a PNET depend on the location of the tumor. The following are the most common symptoms of a PNET, however each child may experience symptoms differently.

Symptoms of a PNET in the supratentorial compartment usually arise quickly and last up to several weeks. These tumors are often seen in the older child or teenager.

Common symptoms may include: -

Increased pressure within the brain, which results in: -

headache (generally upon awakening in the morning)

vomiting

fatigue/lethargy

Seizures Pineoblastomas, or PNETs (pineal region), are usually seen in young children and occur in the area of the pineal gland, a tiny organ near the center of the brain.

Common symptoms may include: -

Increased pressure within the brain, which results in: -

headache (generally upon awakening in the morning)

vomiting

fatigue/lethargy

disturbances in ocular movements and/or complaints of double vision, because the tumor is close to the nuclei (centers in the brain) that regulate eye movements and coordination

Common symptoms of PNET of the spine may include

back and/or leg pain

slow development of weakness in the lower extremities

impairment of bowel and/or bladder function, including incontinence

The symptoms of a brain tumor may resemble other conditions or medical problems. Always consult your child's physician for a diagnosis.

How is a PNET diagnosed?

Diagnostic procedure for PNET may include: -

physical examination and history

computerized tomography scan (also called a CT or CAT scan)- a diagnostic imaging procedure that uses a combination of x-rays and computer technology to produce cross-sectional images (often called slices), both horizontally and vertically, of the body. CT scans are more detailed than general x-rays.

magnetic resonance imaging (MRI) - a diagnostic procedure that uses a combination of large magnets, radiofrequencies, and a computer to produce detailed images of organs and structures within the body. For PNET, MRIs of the brain and spine are usually done. Since these tumors are known to spread via the cerebrospinal fluid (CSF) pathways there is a high incidence of dissemination of the tumor and it is essential that the initial investigations include both a spine and brain MRI, both with and without the administration of contrast.

What are the treatments for a PNET?

Specific treatment for a PNET will be determined by your child's physician based on: -

your child's age, overall health, and medical history

type, location, and size of the tumor

extent of the disease

your child's tolerance for specific medications, procedures, or therapies

how your child's doctors expect the disease to progress

your opinion or preference

Treatment may include: -

surgery - utilized to obtain a biopsy for diagnosis and to remove the tumor. There are data to suggest that aggressive surgical removal is associated with better long-term outcome and, therefore, surgery is appropriately modified to attempt a complete removal. This is usually possible in the supratentorial tumors, but less frequently accomplished in the tumors of the pineal region and rarely in the spine.

radiation therapy - for tumors that are incompletely removed or for tumors that recur, the recommended treatment is radiation therapy to the site of the tumor. Radiation therapy uses high-energy rays (radiation) from a specialized machine to kill cancer cells and shrink tumors.

Usually, the radiation therapy is delivered first, followed by the chemotherapy. In infants, or children under the age of 3, radiation therapy is withheld until they reach the age of 3 years.

chemotherapy - a drug treatment that works by interfering with the cancer cell's ability to grow or reproduce

Different groups of chemotherapy drugs work in different ways to fight cancer cells and shrink tumors. Chemotherapy may be used alone for some types of cancer or in conjunction with other therapy such as radiation or surgery. Often, a combination of chemotherapy drugs is used to fight a specific cancer. Certain chemotherapy drugs may be given in a specific order depending on the type of cancer it is being used to treat. While chemotherapy can be quite effective in treating certain cancers, the agents do not differentiate normal healthy cells from cancer cells. Because of this, there can be many adverse side effects during treatment. Being able to anticipate these side effects can help the care team, parents, and child prepare, and, in some cases, prevent these symptoms from occurring, if possible.

Chemotherapy is systemic treatment, meaning it is introduced to the bloodstream and travels throughout the body to kill cancer cells. Chemotherapy can be given: -

as a pill to swallow

as an injection into the muscle or fat tissue

intravenously (directly to the bloodstream; also called IV)

intrathecally - chemotherapy given directly into the spinal column with a needle

ventriculoperitoneal shunt (also called a VP shunt) - a bypass, usually a type of tubing, that is placed in the head to drain excess cerebrospinal fluid (CSF) from inside the brain to space in the abdomen. A VP shunt helps control the pressure inside the brain. If there is presence of obstructive hydrocephalus (swelling of the brain) in a pineoblastoma, a CSF diversionary procedure, ETV (endoscopic third ventriculostomy) may be necessary. There have been reports of dissemination of pineoblastoma via shunts into the peritoneal cavity and therefore, all efforts are made to avoid placement of a shunt in these children.

How are side effects managed?

The side effects of therapy are those expected with surgery to the specific areas of the brain and those associated with radiation therapy to the brain and spine. These are managed depending on the specific side effects and may include physical and occupational therapy (if there is weakness or sensory loss), and speech therapy (if there is impairment of speech), all on either an inpatient or outpatient basis.

What is the expected outcome after treatment for PNET?

The rarity of these tumors and the difficulty in their classification make it difficult to analyze outcome and survival rates. The overall 5-year survival of patients with PNET is between 50 and 60 percent, but is clearly worse in the sub-group of infants and pineoblastoma patients with incomplete tumor removal or incomplete response to radiation therapy.

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by: pankaj Nagpal

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