Orex And Takeda Partner Up, Stock Update On Crwe And Brcd From Pennytobuck.com

Crown Equity Holdings Inc

Crown Equity Holdings Inc. (OTCBB:CRWE.OB) recently announced that its sales this year have already surpassed $1,000,000. This compares to $232,510 for the three quarters ending September 30, 2009 and $ 659,907 total sales for the year 2009.

Crown Equity Holdings Inc. has expanded its internet footprint internationally to include the following 19 countries: Argentina, Australia, Brazil, Canada, China, France, Germany, Hong Kong, India, Ireland, Italy, Japan, Korea, Mexico, New Zealand, Singapore, Spain, Taiwan and the UK.

Crown Equity Holdings, Inc. is a company utilizing todays technology to advertise, promote and market public companies globally. CRWEs proprietary network technology allows their publishing department to get their content to millions of readers daily across the world. CRWE publishes financial content to all the major countries and covers all the accredited stock exchanges.

Crown Equity Holdings Inc. is a consulting organization which provides and assists small business owners with the knowledge required in taking their company public, and has re-focused its primary vision with its aligned group of independent website divisions to providing media advertising services, as a worldwide online media advertising publisher, dedicated to the distribution of quality branding information, as well as search engine optimization for its clients.

Orexigen Therapeutics, Inc. (Nasdaq:OREX) and Takeda Pharmaceutical Company Limited , recently announced that they have entered into an exclusive partnership to develop and commercialize Contrave , OREX's investigational drug for the treatment of obesity, in the United States, Canada and Mexico.

Contrave is a combination therapy believed to address both biological and behavioral drivers of obesity. The central pathways targeted by this treatment are involved in controlling the balance of food intake and metabolism, and regulating reward-based eating behavior. OREX submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for Contrave on March 31, 2010 and the Prescription Drug User Fee Act (PDUFA) action date has been set for January 31, 2011.

OREX will receive an upfront cash payment of $50 million from Takeda, and Takeda will obtain an exclusive marketing right from OREX in the United States, Mexico and Canada while OREX retains the right to co-promote with Takeda in the United States. OREX will be eligible to receive payments of over $1 billion upon achieving certain regulatory and sales-based milestones. Assuming Contrave is commercialized, Takeda will pay tiered double-digit royalty payments on net sales in the Territory.

Approximately 75 million Americans suffer from obesity and that number is expected to rise to 103 million by 2018. Obesity is a chronic condition linked to serious medical consequences including type 2 diabetes, cardiovascular disease, cancer and depression. Despite increasing public health concerns regarding obesity, two-thirds of the U.S. adult population is overweight or obese. Although weight loss of 5-10 percent may improve overall health, including blood sugar control, high blood pressure, high cholesterol, and overall quality of life, many individuals are not able to lose weight or maintain weight loss with diet and exercise alone.

Orexigen Therapeutics, Inc. is a biopharmaceutical company focused on the treatment of obesity. OREX has filed an NDA with the FDA for its lead investigational product, Contrave. OREX's second product, Empatic, has completed Phase 2 clinical development. Each product candidate is designed to act on a specific group of neurons in the central nervous system with the goal of achieving appetite suppression and sustained weight loss, through combination therapeutic approaches.

Brocade (NASDAQ:BRCD) announced the availability of leading-edge application delivery hardware and software solutions that address the needs of mid-market enterprise customers who are using virtualization and cloud computing solutions to maximize the value of their IT resources.

BRCD introduced a new extension to the Brocade ServerIron ADX 4000 developed to meet the unique needs of mid-market enterprises. The ServerIron ADX 4000 ASM-4 bundle is an entry-level chassis solution that provides industry-leading Layer 4-7 switching performance in a new high-value package to help customers realize the promise of on-demand, automated data center computing. Specifically designed for mid-market enterprise environments, the ServerIron ADX 4000 ASM-4 bundle enables a new class of customers to experience the flexibility and scalability benefits of a modular platform. The license-activated, capacity on-demand scalability of the ASM-4 module enables customers to adopt a pay-as-you-grow investment approach, allowing them to double their throughput and future-proof their application delivery networks without adding hardware or removing the switches from the network. The ServerIron ADX 4000 ASM-4 bundle provides eight ports of 1 Gbps small form-factor pluggable (SFP) copper connectivity, with the option to use fiber SFPs on all ports. It also combines breakthrough performance via a highly robust services platform with built-in extensibility and seamless interoperability across fabrics and networking protocols.

This new offering is the latest in a series of innovations that BRCD has developed to optimize its networking solutions in virtualized IT environments. While server virtualization presents key operational and cost benefits, it has also inherently introduces complexity at the networking level. To address this issue, BRCD recently unveiled Brocade One, a unifying network strategy that illustrates an ongoing commitment to help customers use networking technologies more effectively in migrating towards highly-scalable, simplified and automated virtualized infrastructures. To support this strategy, BRCD has also introduced Brocade Virtual Cluster Switching (VCS), advanced technology that addresses the unique requirements of virtualized data centers. Brocade VCS enables customers to build and manage data center fabrics that can efficiently consolidate and manage tens of thousands of VMs, thereby eliminating the inevitable challenges resulting from traditional Spanning Tree Protocol-based networks.

Brocade develops extraordinary networking solutions that enable todays complex, data-intensive businesses to optimize information connectivity and maximize the business value of their data.

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by: Bill Pennyman

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