Overview Of Drugs Used In Cancer Research

In recent years, cancer has turned out to be one of the most deadly diseases

, which takes up millions of lives every year across the globe. Efforts are underway to find a possible cure to this virulent ailment. There are many bench scientists who are undertaking independent research to find out a cure for cancer. These scientists often require different kinds of antibodies and proteins to continue their research uninterrupted. Today, it is easier for one to find out antibodies suppliers on the internet who offer high quality antibody products at affordable prices. These suppliers stock an adequate quantity of antibody products to help you in cancer research. Mentioned below are some of the most important drugs being used for cancer research.

AZD6244 Also referred to as Selumetinib, AZD6244 is currently being tested for the treatment of different types of cancer including non-small cell lung cancer. Its safety is being investigated to treat cancer patients with a mutated BRAF gene. The drug works by blocking a protein called MEK that plays a crucial role in promoting the growth of cancer cells lines and tumours having mutated BRAF gene.

BEZ235 This PI3K inhibitor is presently being tested for a possible cancer treatment. Also known as NVP-BEZ235, this imidazoquinoline derivative has found to be toxic to Waldenstrm's macroglobulinemia cells. BEZ235 inhibits PI3K kinase and mTOR kinase in the PI3K/AKT/mTOR kinase signalling pathway, which might result in tumour cell apoptosis and growth inhibition in PI3K/mTOR-over expressing tumour cells. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K.

ABT-263 It is one of the most promising substances currently being investigated for the treatment of lymphomas and other types of cancer. ABT-263 blocks some of the enzymes which keep cancer cells from dying. The substance is a type of Bcl-2 family inhibitor and is also referred to as Navitoclax.

Bortezomib This drug is a highly selective and reversible inhibitor of the 26S proteasomes. Bortezomib slows down many proteins which cancer cells need to survive and multiply. The drug has been tested to shown anti-tumour activity in B cell malignancies. It is used for the treatment of patients with relapsed or refractory multiple myeloma.

Crizotinib This substance has found to be quite effective in reducing the growth of tumours in patients suffering from anaplastic lymphoma receptor tyrosine kinase (ALK) positive non-small cell lung cancer. This type of cancer is usually found among people who never smoked. It is also being tested for the treatment neuroblastoma and other advanced solid tumours in both adults and children.

ABT 737 It is one among many so-called BH3 mimetic small molecule inhibitors (SMI) targeting Bcl-2 and Bcl-2-related proteins such as Bcl-xL and Bcl-w but not A1 and Mcl-1, which might prove to be effective for the treatment of lymphoma and other blood cancers.

So, these were some of the most prominent drugs used for cancer research. In case you are a bench researcher and require small quantities of these products, all you need to do is contact a reliable & experienced online antibodies supplier. These experts will help select the best antibody for your cancer research so that you can accomplish great scientific results.

by: Biorbyt

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