Pharmaceutical Excipients: Domestic Situation Worrying Development Effort Yet To Catch Up Abroad -

The continuous development to meet the medical needs of drug production has been

with the formulations, auxiliary materials and the development of technology development. In recent years the development of new pharmaceutical excipients and a large number of applications, which greatly promoted the improvement of formulations and new dosage forms, new kinds of innovation.

According to incomplete statistics, research and production of domestic and foreign agents actually used Accessories , 1000, shows the development and application of accessories have become agents of production in the important part.

Rational application of a new accessories can be a large class of dosage forms corresponding to a large number of new product formulations, and can reach a group of quality integration with the international product standards, which brought incalculable economic and social benefits. Therefore, it can be said, a good development and application of the significance of accessories more than one kind of drug species development. Innovative drug development in today's relatively slow pace, people are constantly developing new uses for old drugs under the premise of drug development has entered the preparation of the times, and drug delivery technology is the main theme of this era, Pharmaceutical Excipients The role of particular significance.

Rapid progress abroad The rapid development of pharmaceutical preparations abroad is inseparable from the development and rational use of excipients. With the world the development of polymer materials, Formulations, endless preparation process, equipment continue to improve, Pharmaceutical Excipients Also followed rapidly. Currently used in various formulations, including controlled release formulations, microcapsules, microspheres, containing materials such as materials, Film coating Material, drug carrier material, solid dispersion carrier, surfactant, immediate-release preparation material, gel material, by type agents, percutaneous absorption material, mucosal preparation material accessories dozens of types of thousands of varieties. In recent years research and development of new accessories developed a specialized agency came into being, developed with a variety of different properties of new materials.

Present, foreign pharmaceutical excipients with polyethylene glycol series, poly carboxymethyl ethylene series, PE Pyrrole Flavanone series, polyoxyethylene alkyl ether series, polyacrylic acid resin, polylactide series, polyoxyethylene alkyl ester polymer series accessories; xanthan gum, cyclodextrin, Prussian blue and other biological Synthesis of polysaccharide accessories; pre-gel starch, sodium carboxymethyl cellulose, carboxymethyl starch sodium, cellulose series semi-synthetic excipients; alginic acid, kainic acid, carrageenan and other plant extracts accessories; chitin, carapace Extraction of sugar and other animal accessories. Accessories dramatic increase in species such as oral preparations for more than one thousand kinds of accessories already (not including specifications and model). According to incomplete statistics, nearly 10 years to overseas development has reached more than 300 kinds of new accessories, and variety, type, full specifications. Such as acrylic resin dozens of different specifications and types of products, polyethylene glycol 33 different specifications of products, fully meet the development of new formulations, new agents need a strong impetus to the pharmaceutical industry.

Advanced countries, particularly the pharmaceutical industry of new accessories focus on applied research, in close connection with the actual production, for the development of new formulations and new varieties of services, to improve product quality and service. The main elements of its research include: chemical and physical properties of new accessories and how it applies to agents of development and production; combination oral preparation process of the production equipment and accessories and drug compatibility properties, the best accessories formulation; for the compatibility between accessories research, combined with the actual national production, design the best composite accessories, such as microcrystalline cellulose and lactose with microcrystalline cellulose and sodium carboxymethyl cellulose as a support.

Developed pharmaceutical excipients trend is the specialization of production, Variety Series, and scientific applications by multinational companies to promote all-round way.

Worrying domestic situation Application of Pharmaceutical Excipients

China has a long history, as early as 1766 BC, water as solvent to create the world's first pharmaceutical preparations?? Decoction, started with animal glue, honey, starch, vinegar, vegetable oil, animal oils as pharmaceutical excipients. In 1980, the oral solid dosage pharmaceutical excipients start applications, including starch, sugar, dextrin, lactose, magnesium stearate. However, due to less variety accessories to make preparations following problems: poor quality (appearance, hardness, disintegration, dissolution, bioavailability and efficacy of the poor); limit the preparation of new solid dosage forms, development of new varieties; Traditional Accessory specification itself incomplete, inconsistent quality (such as fineness, purity, heavy metals and other indicators). Therefore, after 80s of last century, at the time of the State Pharmaceutical Administration of the leadership and support of the National scientific research units, universities, medical accessories manufacturers together to trial, application and promotion of new accessories.

by: gaga

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