Poly(ADP-ribose) polymerase (PARP) Research Products

Poly(ADP-ribose) polymerase (PARP) Research Products

Overview: This PARP Research Products market report explores are a superfamily of 18 proteins, of which PARP-1 is the best characterized. They are enzymes that are activated by DNA breaks to facilitate DNA repair.

Currently, there is a great deal of research being done on this family of polymerases, because its activity is linked to serious disease conditions, including cancer, ischemia, diabetes, arthritis, inflammatory bowel disease, and septic shock. Of greatest therapeutical interest are PARP-1 inhibitors, as they exert a duel effect of inhibiting cell death and reducing inflammation. Indeed, these inhibitors have been shown to be effective as radiation-sensitizing agents and appear promising in the treatment of conditions involving oxidative stress. Additionally, quantification of poly(ADP-ribose) polymerase activity and identification of abnormal patterns of its degradation by proteases might have utility in the diagnosis various conditions.

At this time, there are a limited number of research products available to this research community. Commercially available research tools include enzymes, antibodies, inhibitors, and assay kits designed for the measurement of poly(ADP-ribose) polymerase activity. Because of the size and growth potential of this research products market, providing products to this market niche represents a significant financial opportunity. This report is an in-depth exploration of this research products market, including market conditions, dominant competitors, clinical applications, and product opportunities available to companies interested in this lucrative, early-stage market.

Table of Contents :

I. ABSTRACT

II. BACKGROUND

A. Introduction

B. PARP Superfamily

1. Characterized Isoforms

2. Comparison of domain structures of PARP isoforms

C. Active / Inactive States of PARP-1

D. Severity of Damage Regulates Repair Processes

E. Regulation of DNA Repair by NAD

F. PARP-1 Inhibition

G. PARP-1 Degradation by Proteases

III. APPLICATIONS

A. Basic Research

1. Current Applications

2. Future Applications

B. Diagnostic Applications

1. Current Applications

2. Future Applications

C. Future Applications

1. Current Applications

2. Future Applications

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