Research On Glutathione S Transferase M1 Genotype And Susceptibility Of Gastric Cancer

Molecular epidemiological studies find that the occurrence of tumors is caused by the carcinogens in the environment

. Long-term exposures to a sufficient amount of carcinogen are likely to cause the tumor for all individuals in theory. But in fact, only a small number of contactors get disease. The individual's response to the carcinogen are significant different. Namely, there are different tumor susceptibilities. The tumorigenesis is mainly activated and jointly controlled by oncogenes and tumor suppressor gene inactivation. The individual tumor susceptibility differences exist in each stage of the cancer. At the start-up phase of the cancer, metabolic enzyme gene polymorphisms determines the environmental carcinogens The effect of agent plays a key role on glutathione sulfur enzyme gene polymorphism and gastric cancer, colorectal cancer and other gastrointestinal tumors susceptible. The researches are also very active.

Studies have shown that the occurrence of gastric cancer associated with age, sex, educational level. It is found that in the adjustment of these four factors, the occurrence of gastric cancer and the GSTM1 null genotype, Hp infection, garlic as a protective factor, GSTM1 null gene type and smoking a synergistic role of Hp infection on gastric carcinogenesis. A higher prevalence of male gastric cancer, male to female ratio is about 2 to 3:1; age of onset of mostly middle-aged, young people less, 40 to 60 years accounted for about 2/3, the age of 40 accounted for 1/4 I over 60 years, gastric cancer occurs in the lower socio-economic strata.

Metabolizing enzymes are divided into phase I metabolic enzymes and II metabolizing enzymes, exogenous carcinogens can start the cancer process, depending on the result of the interaction of the two types of metabolic enzymes, and metabolic enzyme activity and substrate specificity mainly by individual alleles are OK. GSTM1 genotype have a synergistic effect of Hp infection in gastric carcinogenesis, although the exact mechanism is not clear, but can be speculated that the genotype may Hp some genotoxic metabolites or infection by Hp carcinogenic the metabolism to genetic defects, and thus easier to develop into gastric cancer in the same exposure, this view is the lack of direct evidence, further research needs to be confirmed.

Epidemiological data show that the Hp infection and gastric cancer occurred in the socio-economic background, geography, time, and pathological aspects of a striking wave line disease. Hp infection rate was higher in the populations of poor socio-economic situation has also found an increased risk of gastric cancer. The occurrence of gastric cancer is a long process of Hp infection on gastric carcinogenesis may play a key role, because the effect of carcinogenic factors related to the exposure time, developing countries Hp infection rate, and many childhood infections after a certain period of time can lead to atrophic gastritis, intestinal metaplasia and dysplasia, thereby increasing the risk of gastric cancer.

Smoking and a blank of GSTM1 gene genotype play a synergistic effect on the occurrence of gastric cancer and chronic atrophic gastritis. Eating garlic can prevent gastric cancer. Garlic belongs to liliaceae allium underground bulbs. It is widely used in worldwide and becomes one of recognized pharmaceutical raw materials. Individuals with the susceptible genotype have a higher sensitivity to the environmental carcinogens such as tobacco as benzopyrene, nitrosamines. Therefore, for this part of the crowd, people should give closely monitored. It helps to early detection of gastric cancer. This crowds eating habits also need health guidance, such as smoking cessation, the eradication of Hp increase the intake of garlic and health food. They may reduce the incidence of gastric cancer and play an important role.Source:http://www.cospcn.com

by: anelwew

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