Scientists Have Learned How To Diagnose Appendicitis In Urine

Air pollution and other emissions into the atmosphere may be one of the causes of

an acute inflammation of the appendix, requiring immediate surgical intervention. That is the conclusion reached by Canadian scientists, comparing the data on air pollution with the number of hospitalizations due to appendicitis. Comparing the local information on air pollution a summary of the hospitals, they found an association between elevated levels of ozone and nitrogen dioxide with an increase in admissions to hospital with appendicitis.

Scientists hope that they managed to develop a simple and affordable analysis of urine that can help in the diagnosis of appendicitis. This disease can be life threatening, it is very difficult to diagnose, especially in adolescents, and it requires urgent surgical intervention.

Team of researchers from Children's Hospital in Boston has discovered a protein in the urine, which, as it seems, can serve to recognize appendicitis. Such a simple method for diagnosis of the disease would be an obvious breakthrough that will help reduce the risk of complications typical of advanced cases, as well as prevent unnecessary removal of healthy organs in the case of a wrong diagnosis. Statistics show that about 30% of children are on the surgery table, when there is no need, and at the same time, 45% of surgery is performed after the development of complications, which is too late.

The Boston team has used the technology of mass spectrometry to analyze 12 samples of infant urine. Scientists have identified 57 compounds related to immune response and inflammation, which potentially could indicate the development of appendicitis. Further tests, collected from 67 children hospitalized with suspected appendicitis, have narrowed the search to 7 compounds. The best indicator was leucine rich alpha-2-glycoprotein (LRG). Scientists have observed that a higher level of LRG is directly linked to the disease, even if the other tests gave negative results. It also turns out that the higher the level of LRG, so the harder is disease.

The researchers acknowledge that their data may be relevant only to children, and that markers of disease in adults may differ. In addition, it is necessary to clarify whether LRG is specific for the diagnosis of appendicitis, and is it linked with other concomitant disease states. "The main question is whether surgeons and patients may trust this analysis, if it would be contrary to the clinical picture, - said Dr. Jeffrey Glazer (Geoffrey Glazer) from Wellington Hospital, London, - the surgeon chooses to remove a healthy appendix in order not to miss ill one.

by: Michael Smith

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