Spontaneous Humoral Immune Response to Mesothelin in Humans

A total of 12 mesotheliomas (six mixed type and six epithelioid type) and 13 carcinomas

(eight adenocarcinomas and five large cell undifferentiated carcinomas) were studied.

The results revealed a clear difference between mesotheliomas and adenocarcinomas: 11 of 12 mesotheliomas showed coexpression of vimentin and cytokeratins in at least 50% of the tumour cells, while in seven of the eight adenocarcinomas none or only a few cells could be seen with this coexpression. In the undifferentiated large cell carcinomas three of five expressed both components, but in less than 25% of the cells. It is concluded that a reliable double immunoenzyme staining of vimentin and cytokeratins can be used as an additional means to distinguish malignant mesothelioma from pulmonary denocarcinoma."

Spontaneous Humoral Immune Response to Mesothelin in Humans

By: Montwrobleski77

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