Stem Cells Used To Grow Human Liver In Laboratory

In what researchers at Newcastle University in the U.K

. have dubbed a "eureka moment," a miniature human liver has been grown artificially in a laboratory through the use of stem cells, which may mean that in the future, full-sized organs could be artificially grown for transplants.

Tissues such as this one could also be used to test the effects of new drugs, circumventing disasters such as the TGN-1412 trial. In that test, now known in the press as the "elephant man drug trial," the bodies of six volunteers flared up to dangerous levels after being administered an experimental drug, leaving at least one with terminal cancer. Having artificial tissue to test on could also mean fewer animal experiments, the researchers noted.

Within five years, grown liver tissue could repair livers damaged by injury, disease, alcohol abuse, and over-the-counter painkiller overdose, and entire livers could be quickly replaced roughly 15 years from now, the researchers said. In 2004, 72 people in the U.K. died while waiting for a suitable transplant donor, and there are currently 336 people on the liver transplant list there.

The miniature liver, approximately the size of a penny, was grown from stem cells. These blank cells are found in the blood from the umbilical cord and can be turned into specific types of tissue when removed from the umbilical cord minutes after a baby is born. Scientists then place the cells in a NASA-developed "bioreactor," which simulates weightlessness. Without the effects of gravity, the cells multiply more quickly, after which various hormones and chemicals are added to cause the stems cells to transform into liver tissue.

Stem cell research, especially embryonic stem cell research, has caused a lot of controversy since it usually requires the destruction of a human embryo, but this technique is considered more ethically acceptable as no such destruction is required.

The Newcastle researchers postulated a worldwide donor register for liver dialysis and transplant could be formulated if the umbilical blood of millions of babies is preserved each year, using a computer registry to track blood compatibility. More than 11,000 British parents already freeze their children's umbilical blood, which is used to treat leukemia.

"One hundred million children are born around the world every year -- that is 100 million different tissue types," said Colin McGuckin, professor of regenerative medicine at Newcastle University. "With that number of children being born every year, we should be able to find a tissue for me and you and every other person who doesn't have stem cells banked."

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by:Anjuri

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