The description of Albendazole
The description of Albendazole
The description of Albendazole
Albendazole is a broad-spectrum anthelmintic efficiency and low toxicity. Can be used to drive the clinical roundworm, pinworm, tapeworm, whipworm, hookworm, round worm manure and so on. Metabolism in the body sulfoxide or sulfone class, the inhibition of parasite uptake of glucose, resulting in parasite glycogen depletion, or inhibition of fumarate reductase system that prevents the production of ATP, the parasite can not survive and reproduce.
Alias: propylthiouracil of yl, albendazole, anti-creep Min, Seoul insects flutter, intestinal worms clear, ZENTEL, A
[Albendazole Molecular formula]
Albendazole Molecular formula
BENTEL
Drug characteristics
Albendazole is white or almost white powder, odorless, tasteless, insoluble in water, slightly soluble in acetone or chloroform.
Pharmacology and toxicology
Department of benzimidazole derivatives, albendazole, and its rapid metabolism in the body as sulfoxide, sulfone alcohol and 2 - amine sulfone alcohol.
[Albendazole]
Albendazole
On selective and irreversible intestinal nematode parasites of the intestinal wall to inhibit the cytoplasmic microtubule polymerization, blocking its uptake of various nutrients and glucose absorption, leading to insect endogenous glycogen depletion, and inhibition of fumarate reduction enzyme system, to prevent the production of ATP, resulting in parasites can not survive and reproduce. With mebendazole similar, the goods can cause intestinal parasites cytoplasmic microtubules degeneration, and its tubulin binding, causing blockage of intracellular transport, resulting in Golgi accumulation of endocrine granules, the cytoplasm gradually dissolved, absorption cells completely denatured, death caused by parasites. This product has completely killed the hook and whip eggs and some eggs to kill the role of Ascaris eggs. In addition to get rid of parasites on animals to kill a variety of nematodes, tapeworm and cysticercosis are also evident on the kill and get rid of role.
Toxicology tests showed that the toxicity of the product, safety. Mouse oral LD50 is greater than 800mg/kg, the maximum tolerated dose in dogs oral 400mg/kg or more. The drugs on male reproductive function in mice had no effect on female mice and no teratogenic effects in female rats and female rabbits, application of larger doses (30mg/kg / day), it can absorb and bone of fetal malformations.Listen
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