Where is Cholesterol Made?

Where is Cholesterol Made?

Where is Cholesterol Made?

There is the cholesterol that is taken in by food (mainly from meats), and there is the cholesterol that your body naturally produces. The majority of your body's natural cholesterol is made in the liver, with the average person manufacturing anywhere between 700 and 1,200 milligrams per day (adult women who are pre-menopause naturally create more HDL cholesterol than men of the same age). Other, smaller amounts of cholesterol are made in certain areas of the intestines, and by individual cells in the body. This cholesterol is used in the production and synthesis of other vital bodily functions, such as bile for digesting fat and hormones.

Inside of the liver, complex biochemical reactions are taking place to create cholesterol. The process begins with the very common 2-carbon molecule known as Acetyl-CoA (C2). From here, the liver goes through the processes of converting the Acetyl to different carbon molecule compilations. Chemically, the production appears as follows: C2 (Acetyl-CoA) - C6 (Mevalonate) - C5 (isopentenyl pyrophosphate) - C30 (Squalene) - C27 (Cholesterol). As shown, the process ends with C27 , the chemical compound for cholesterol.

Surprisingly to most, the human body is designed to manufacture all of the cholesterol that it needs to perform the various functions that it is seen in. In fact, when the doctor measures your cholesterol level, they are actually measuring the amount of cholesterol that is circulating through your blood. This is more formally known as a blood cholesterol level. In these tests, it is average to see that 85% of the cholesterol present is what your body produces, leaving 15% to what you take in.

For some, balancing cholesterol levels is simple, because their body reacts to their intake daily, maintaining a level of basic homeostasis. However, certain individuals have to carefully regulate their diet in order to take in appropriate amounts of cholesterol. This phenomenon can be blamed on genes. There are genes that are passed down from both the mother and father's side of the gene pool that effect the creation and distribution of your body's natural cholesterol. As stated above, some people are capable of creating an amount of cholesterol that is based on their daily intake. However, for some, the body creates a consistently low amount of cholesterol, increasing the risk of digestive issues. For others, the body creates an excess amount of cholesterol. While both low and high cholesterol levels are dangerous, high cholesterol can be attributed to many heart related issues, and other medical issues, such as gallstones.

Genes aren't all to blame, though, and everyone must understand that the differences in each person are best explored with your own doctor, in order to determine the best cholesterol diet for you and your family. It is also important to remember that while genes play a roll in your individual cholesterol production, the option for an innate cholesterol imbalance does not have to occur in your family line for it to occur in you - it is simply more likely.

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