Asbestos a Complete Carcinogen or Just a Promoter Trying to better understand the mechanism of mesothelioma disease has been the goal of many researchers. Some believe that a threshold may exist between duration and intensity of asbestos exposure and the induction of mesothelioma. One interesting study is called, "Possible role of lipid peroxidation in the induction of NF-kappa B and AP-1 in RFL-6 cells by crocidolite asbestos:...more
Understanding Cellular and Enzyme Responses of Chrysotile Asbestos Occupational exposure to asbestos causes the death of thousands of people each year. This has led to an almost unparalleled body of research trying to better understand asbestos and its link to mesothelioma disease. One interesting study is called, "Kinetics of the bronchoalveolar leucocyte response in rats during exposure to equal airborne mass concentrations of...more
Asbestos Inhalation Nitrate Levels and Cellular Mutation When asbestos fibers are broken into small pieces they can be swallowed or inhaled and lead to mesothelioma disease. This disease is responsible for the deaths of thousands of people each year, and consequently is the subject of a great deal of research. One important study is called, "Secreted extracellular domains of macrophage scavenger receptors form elongated trimers which specifically bind crocidolite asbestos" by D Resnick, N J Freedman, S Xu and M Krieger - February 15, 1993 The Journal of Biological Chemistry, 268, 3538-3545. Here is an excerpt: "Abstract - Macrophage scavenger receptors, which have been implicated in the development of atherosclerosis and other macrophage-mediated events, are trimeric integral membrane glycoproteins whose extracellular domains have been predicted to include alpha-helical coiled-coil, collagenous and globular structures. To elucidate further the structural and functional properties of these receptors, we generated transfected Chinese hamster ovary cells which express secreted extracellular domains of the type I and type II bovine scavenger receptors and developed a...more
Clustering of Mesothelioma Cases and Asbestos Exposure When asbestos fibers are inhaled, they can attack the membranes surrounding the heart, lungs and abdomen and lead to disease development. Mesothelioma alone causes the death of over 2,000 people each year. Identifying the links between this deadly disease and asbestos exposure are...more
Blue Collar Workers and the Mesothelioma Menace Manual laborers suffer from mesothelioma disease in an inordinate amount. This has been the subject of much research. One important study is called, "Analysis of the cores of asbestos bodies from members of the general population: patients with probable low-degree exposure to asbestos" by...more
Asbestos Fibers Disrupt Chromosome Behavior The development of mesothelioma disease has been linked to asbestos exposure. One interesting study examining this relationship is called, "The Hygiene Standard for Chrysotile Asbestos" - The Lancet, Volume 311, Issue 8062, Pages 484-489. Here is an excerpt: "Abstract - Previous studies, including the analysis on which the current 2 fibres/cm3 hygiene standard is based, may have underestimated the risk of morbidity or mortality following exposure to low levels of asbestos dust. Accurate dose-response data at levels below 2 fibres/cm3 are unlikely to be available for the foreseeable future, and the biologically plausible assumption that excess cancer mortality is approximately proportional to dust level should be provisionally accepted. It may be reasonable, however, to postulate a safe threshold for mortality from asbestosis. If excess mortality from asbestos-related disease is proportional to dust level for each cause, approximately 10% of male asbestos workers might, under certain assumptions, eventually die of asbestos-induced disease after 50 years' exposure at 2 fibres/cm3. Peritoneal mesothelioma is usually due to...more
Asbestosis - How "Coffin Nails" Can Really Become Coffin Nails Asbestos causes a host of health problems. One that doesn't get as much hype is asbestosis. In this article, we take a look at asbestosis and smoking.Asbestos is a...more
As a result of its location on the eastern coast of Canada, it has low temperatures for a large part of the winter. Temperatures during that time can be cold and there is snow during the winter months.The city of Toronto has numerous universities...more
It's been well over one hundred years since lung diseases were first linked to asbestos. Nonetheless, because asbestos is so durable and because it is so resistant to fire, chemicals, and heat, it had been used extensively in the construction...more
W.R. Grace and Co. purchased the asbestos mining facility in Libby, Montana in 1963. The mine, which employed more than 1,900 people, had been operational since 1924.One of the biggest vermiculite mines in the world, at the peak of its production...more
How Can A Mesothelioma Occur Mesothelioma is the name employed to describe a tumor of cancerous that affects the mesothelium of organ cells, generally the heart, lungs, abdominal organs and a number of few further components of the body....more
Asbestos Crusher What is asbestos and how to crush asbestos Asbestos refers to a small number of minerals that are formed of flexible fibers, and have the useful physical property of being very heat resistant. Because asbestos forms as flexible...more