mast cell tumors
mast cell tumors
mast cell tumors
What is the prognosis for dogs with mast cell tumors?
These include vinblastine, lomustine, and corticosteroids, such as prednisolone. In determining the appropriate therapy or treatment for mast cell tumors and their wide variety of forms, it is important to remember that each animal needs to be evaluated and treated individually.
Unfortunately, mast cell tumors do not respond well to these drugs.
The prognosis depends primarily upon the grade and stage of the tumor. This is the treatment of choice, and if performed correctly, will usually cure Grade I and Grade II tumors. In these instances, radiation is recommended. Treatment consists of surgical removal and radiation, and possibly chemotherapy. If the mast cell tumors have spread to multiple areas, a combination of anti-cancer drugs are commonly used along with surgery and radiation. Dogs with tumors on the limbs appear to have the best prognosis. There is a new weapon available in the fight against canine mast cell tumors. There are some strict warnings and handling instructions with this medication so Palladia should only be administered to dogs that are under a veterinarian's care.
It is given orally and works in two ways: it attacks and kills the tumor cells and it cuts off the blood supply to the tumor. Conclusion
In some cases, surgical removal may not be an option, or it may not be possible to remove enough margin around a tumor. Mast cell tumors can present in a wide variety of ways and can have an equally varied set of symptoms and outcomes. How are mast cell tumors treated?
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This drug is marketed by Pfizer Animal Health under the trade name Palladia. This medication is a tyrosine kinase inhibitor called toceranib phosphate.
It is sometimes difficult to determine exactly where the tumor begins and healthy tissue starts, so a wide margin (large portion of healthy tissue around the tumor, at least one inch) should be removed along with the tumor.
Those with tumors in the nail bed, genital areas, muzzle, and mouth have a poorer prognosis. Radiation is most useful when the tumors have not spread to multiple areas of the body.
Chemotherapy
Palladia is a prescription medication designed to treat grade II-III, recurrent, mast cell tumors of the skin. Dogs with mast cell tumors in the internal organs, such as the spleen or bone marrow, have the least favorable prognosis.
Mast cell tumors are usually treated by surgical removal. In addition, dogs with Stage I tumors have the best prognosis, compared to those staged higher. As with all tumors, prompt recognition and treatment is very important in obtaining the best possible outcome. The lower the grade, the better prognosis. Radiation
Radiation therapy after surgical removal appears to be beneficial and may reduce the incidence of reoccurrence and increase survival rates.
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