subject: Prevention of HSV Infections [print this page] Author: bcured Author: bcured
Because of the increased awareness of the increasing incidence of genital herpes and neonatal herpes and the association between HSV infection and an increased risk of acquiring HIV, every effort should be made to prevent HSV-2 infections. Until a vaccine is proved effective, educational efforts must be developed for adolescents and adults at greatest risk. The use of condoms should be promoted. Individuals known to be infected should be educated about the risks of transmission of infection, particularly to seronegative female sexual partners who are pregnant. In addition, the incidence of neonatal HSV infection can be decreased by performing a cesarean section if lesions are present in the mother at delivery. Vaccination remains the ideal method for prevention of viral infection, but the use of vaccination to prevent HSV infections introduces unique problems because of recurrences in the presence of humoral and cell-mediated immunity. The vaccines that have been studied to the greatest extent are subunit glycoprotein constructs. Alternative approaches are to genetically engineer HSV to create an attenuated construct or to administer naked DNA. Naked HSV DNA vaccines are now in phase 1 trials in humans. On the other hand, knowledge of the g134.5 gene of HSV-1 as a mediator of CNS replication has just now been taken into consideration in the engineering of HSV. Furthermore, deletions of g134.5 significantly decrease the ability of the engineered viruses to establish latency. Such constructs in HSV-2 are being developed. Other approaches to the manipulation of HSV, including mutations in ICP8 and gH, are under way for vaccine development. Acyclovir, a synthetic acyclic purine nucleoside analogue, has become the standard of therapy for HSV infections. It is the most widely prescribed and clinically effective antiviral drug available to date. The prodrug valacyclovir and famciclovir have recently been licensed and have greater oral bioavailability than acyclovir and penciclovir. Treatment with acyclovir, valacyclovir, and famciclovir is associated with some adverse effects. Renal dysfunction has been reported, especially in patients given large doses of acyclovir by rapid intravenous infusion, and appears to be common. Sometimes, the risk of nephrotoxicity can be minimized by administering acyclovir by slow infusion and by ensuring adequate hydration. Oral acyclovir therapy, some even at doses of 800 mg five times daily, has also been associated with renal dysfunction. A few reports have linked intravenous administration of acyclovir with disturbances of the CNS, including agitation, hallucinations, disorientation, tremors, and myoclonus. For those with prenatal exposure to acyclovir, the risk to mothers or fetuses shouldn't be ignored. Since acyclovir crosses the placenta and is concentrated in amniotic fluid, there is concern about the potential for fetal nephrotoxicity, although none has been observed. As the significant adverse effects, the need for the development of new effective antiviral agents has arised. Alternative antiviral herpes cures are being investigated with great interest. Recent scientific studies of medicinal antiviral plant extracts show very encouraging results for a herpes cure, and have sparked a new methodology for treating herpes. Studies of these antiviral extracts demonstrate that many of these compounds exhibit significant anti-herpetic activity. Several actually inactivate HSV with great effectiveness. These antiviral extracts represent new effective treatment options for therapeutic use as virucidal agents for recurring herpes infections. HSVCurative is a potent all natural antiviral cure for herpes, highly effective against HSV1 and HSV2; it has a wide spectrum of antiviral activity against these viruses. The cure in this treatment has the ability to inactivate and destroy HSV, which has been established in published clinical trials. HSVCurative contains certified organic medicinal plant extracts and antiviral essential oils which cause cellular death to HSV1 and HSV2 in scientific studies. It is to be applied directly to an outbreak. The herpes cure applied to lesions or open sores is quickly absorbed into the circulatory system in significant quantities; hence use of organic material is absolutely essential in herpes cures. HSVCurative is certified organic and is meant for medicinal use. To learn more, please go to http://www.bcured.net.About the Author:
staff of Nature Power Company, which is a network company dedicated to promoting customers' websites and developing softwares. You can go to the following websites to learn more about our natural organic products. http://www.bcured.nethttp://www.naturespharma.org
