subject: Pathogenesis of uterine fibroids [print this page] So far, the cause of uterine fibroids is not yet clear. According to a large number of clinical observations and experimental results show that fibroids are estrogen dependent growth of a tumor. Such as clinical common in women of childbearing age, 30 to 50 years of age, especially in the high-estrogen environment, such as pregnancy, high estrogen and other exogenous growth was the case, while gradually shrinking fibroids after menopause. Fibroid patients and often accompanied by ovarian congestion, swelling, excessive endometrial growth, which revealed excessive estrogen stimulation.
uterine fibroids with a substantial relationship between endocrine disorders. Application of exogenous hormone and clomiphene increases uterine fibroids after, inhibition of sex hormones can prevent or reduce the growth of fibroids, shrinking fibroids and improve clinical symptoms.
View from the tissue, uterine fibroids from the uterine muscle cells, vascular smooth muscle cells without wall into mature muscle cells, but the latter not yet clear on the concept of organizational learning. The occurrence of human uterine fibroids may come from undifferentiated mesenchymal cells to smooth muscle cell differentiation process. Multiple origins of uterine leiomyoma cells may be due to multiple foci in the myometrium potential. Into sexual maturity, remaining in the undifferentiated mesenchymal muscle cells and mature smooth muscle cells in estrogen and progesterone appear under their own continuous cycle proliferation, differentiation and hypertrophy, repeated over time, the final form tumors.
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