subject: Migraine: No Ordinary Headache [print this page] Conventional treatment focuses on identifying and avoiding migraine triggers, and attempting to manage symptoms when a migraine strikes. Most sufferers need to lie down in a dark, quiet room. Over the counter pain medications aren't typically effective against a migraine. Prescription migraine medications are the most valuable approach to pain relief, particularly sumatriptan succinate, brand name Imitrex. Migraine medication is most effective if taken at the first signs of an attack.