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subject: Drug Formulation [print this page]


Drug formulation is defined as the process by which different dugs are brought in together for manufacturing a medicinal product. The formulation process of drugs involves inspection of different drugs. During the inspection of the drugs several factors such as solubility of the drugs, the particle size of the drugs, polymorphism and pH are given due consideration since it can have a significant effect on the action of the drug.

Today, several major pharmaceutical companies around the world are investing heavily on R&D (Research and Development) of new and better drug delivery and drug formulations systems. The research is focused to develop new medicines and vaccines for several diseases with state of the art computational manufacturing processes.

The time required for drug formulation process varies depending on the characteristics of the drug. The process of the early drug formulation takes about 1-2 months. Whereas, the full formulation process of drug including the stability studies generally takes about 2-6 months. Formulation process for drugs in powder form takes less time while formulation process for drugs in tablet and capsule form takes long time.

Types of drug formulation:

Oral Formulation:

Oral formulation of drugs involves formulating drugs in to capsules and tablet form. Drug formulated in a tablet is mainly made from compressing 5-10% of actual drug, glidants, lubricants (80%), disintegrants, binders and 10% of compounds that helps easy disintegration and disaggregation of the tablet in the stomach. In the capsules manufactured this way, the prime active ingredient is enclosed within a gelatinous envelope. The capsule is designed in such a way that the active ingredients of the capsule remain intact for a considerable period of time after ingesting the capsule and delaying the absorption process.

Topical medication form:

Topical medication form includes formulating drugs in different forms such as ointments, pastes, creams, powder and gel forms.

by: Jenny Birkin




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