subject: Topical Minoxidil - A Popular Hair Loss Treatment [print this page] Minoxidil would not be so effective unless it is used on a continual daily basis for at least two months. The longer the better, some people choose to continue for a period of up to six months until their hair loss problem has completely disappeared. When you stop using the medication there is every chance that you will retain your new head of hair. If the problem arises again then you should go back to using topical minoxidil.