subject: Know About The Of Inflammation And Age Related Disease [print this page] It is one of the fact that the biological mechanisms underlying telomere shortening are generally thought to be oxidative stress and inflammation. Increased oxidative stress has been shown to increase rates of telomere shortening in vitro. Using this theory to explain the results his group saw in the west of Scotland study, Professor Samani noted that coronary heart disease is a chronic inflammatory process, with oxidative stress contributing to atherosclerosis. "The risk associated with conventional risk factors for coronary artery disease, such as hypertension, smoking, and diabetes, could also be partly mediated through increased telomere attrition from oxidative stress."
A study of older people participating in the US Cardiovascular Health Study supports this hypothesis.6 Results showed that shorter telomere length was associated with diabetes, blood glucose and insulin concentrations, diastolic blood pressure, thickness of the carotid intima-media, and interleukin-6 concentrations.
Studies have shown that telomere shortening is associated with several age related conditions, including cardiovascular disease, diabetes, and vascular dementia. "We know that people with specific diseases have shorter telomeres than people of the same age without that disease," explains Dr Fitzpatrick.
Associations with telomere length have been reported for several disease risk factors, including hypertension, insulin resistance, obesity, and atherosclerosis. Shorter telomeres have also been found in women under chronic, severe stress.
Blood samples collected during major epidemiological and clinical trials are proving a rich hunting ground for information on telomeres and disease risk. Telomeres isolated from leucocytes are measured and the length compared between disease cases and controls.
Professor Samanis group has shown that average telomere length is shorter in people who have had a myocardial infarction before the age of 50 years than in controls matched for age and sex. Telomeres are also shorter in patients with severe triple vessel coronary artery disease than in people with angiographically normal coronary arteries.
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