subject: Albendazole Belongs To The Benzimidazole Chemical Family Of Anti-worm Medications [print this page] A method for treating a mammal patient having a neoplasm, said method comprising administering to said patient an effective amount of drug selected from the group consisting of cinnarizine; desipramine; fenofibrate; flunarizine; reserpine; isoreserpine; nicardipine; promazine; promethazine; suloctidil; terfenadine; atorvastatin; mebeverine; sertraline; albendazole ; bepridil; bergaptene; clomiphene; dichlorophene; droperidol; mebendazole; meclocycline; metergoline; ramiphenazone; sanguinarine; dipyrone; nicardipine; or 4-dimethylaminoantipyrine; or a metabolite or analog thereof; wherein said neoplasm is sensitive to said drug or a metabolite or analog thereof.
A composition, wherein a drug selected from the group consisting of cinnarizine, desipramine, fenofibrate, flunarizine, isoreserpine, reserpine, nicardipine, promazine, promethazine, suloctidil, terfenadine, atorvastatin, mebeverine, sertraline, albendazole, bepridil, bergaptene, clomiphene, dichlorophene, droperidol, mebendazole, meclocycline, metergoline, ramiphenazone, sanguinarine, dipyrone, nicardipine, or 4-dimethylaminoantipyrine, is present in amounts that, when administered to a patient having a neoplasm, reduce cell proliferation in said neoplasm.
Albendazole tablets is an anthelmintic (anti-worming) medication. It stops the larvae from growing and starves them to death by preventing them from utilizing glucose.Albendazole belongs to the benzimidazole chemical family of anti-worm medications. The medications were effective and wildly used, particularly with farm animals. However, worms are becoming resistant to them, and they are more toxic than many newer drugs.
The cancer treated according to any of the methods of the invention, described below, can be lung cancer (squamous cell carcinoma, adenocarcinoma, or large cell carcinoma), brain cancer, breast cancer, cervical cancer, colon cancer, gastric cancer, kidney cancer, leukemia, liver cancer, lymphoma, ovarian cancer, pancreatic cancer, prostate cancer, rectal cancer, sarcoma, skin cancer, testicular cancer, or uterine cancer.
The invention also features methods for identifying compounds useful for treating a mammal patient having a neoplasm. The method includes the steps of contacting cancer cells in vitro with (i) cinnarizine; desipramine; fenofibrate; flunarizine; reserpine; isoreserpine; nicardipine; promazine; promethazine; suloctidil; terfenadine; atorvastatin; mebeverine; sertraline; albendazole bolus ; bepridil; bergaptene; clomiphene; dichlorophene; droperidol; mebendazole; meclocycline; metergoline; ramiphenazone; sanguinarine; dipyrone; nicardipine; or 4-dimethylaminoantipyrine; and determining whether the cancer cells grow more slowly than cancer cells that are untreated or are treated with a vehicle or an inactive compound.
Worm infestations can make your dog very sick or kill it. A vet will determine the right medication for your dog based on the type of worms the dog has, usually diagnosed by a fecal exam.Albendazole is effective in killing pork and tape worms, capillariasis (roundworms), treating Giardia and decreasing worm cyst shedding.
The invention also features a method for treating a patient having a neoplasm, said method comprising administering to said patient a therapeutic and effective amount of a drug selected from the group consisting of cinnarizine; desipramine; fenofibrate; flunarizine; reserpine; isoreserpine; nicardipine; promazine; promethazine; suloctidil; terfenadine; atorvastatin; mebeverine; sertraline; albendazole oral suspension ; bepridil; bergaptene; clomiphene; dichlorophene; droperidol; mebendazole; meclocycline; metergoline; ramiphenazone; sanguinarine; dipyrone; nicardipine; or 4-dimethylaminoantipyrine; or a metabolite or analog thereof; wherein said neoplasm is sensitive to said drug or a metabolite or analog thereof.
Unless otherwise indicated, the compounds useful for practicing the invention are meant to include pharmaceutically acceptable salts, prodrugs thereof, enantiomers, diastereomers, racemic mixtures thereof, crystalline forms, non-crystalline forms, amorphous forms thereof and solvates thereof. Albendazole has many side effects, including blood cell (hematologic) toxicity, leucopenia (abnormally low white blood cell count), lethargy, bone marrow toxicosis, vomiting, diarrhea and loss of appetite, and it may cause pregnant bitches to abort or have damaged puppies. With new drugs that are less toxic and more effective, it is used less often.If your dog has not responded to other medications or if it has several types of worms, albendazole suspension alone or with other drugs may be required to treat the worm infestation. Your vet will monitor for adverse effects.
