subject: Skeletal Muscle Relaxant In The Development Of Our Country Is In A Golden Age - Muscle Relaxants - [print this page] Skeletal muscle relaxants, also known as muscle relaxant, appeared in 1942 and began clinical application. Muscle relaxants act on the neuromuscular junction, postsynaptic membrane (motor end plate) on the N2 receptors, blocking the normal transmission of nerve impulses, causing muscle relaxation. Muscle relaxant general anesthesia can be used as auxiliary agents. Application of muscle relaxants, may in shallow Under general anesthesia, surgery was required degree of muscle relaxation, thus reducing the amount of anesthetics. Muscle relaxants allow the clinical feasibility and safety of anesthesia greatly improved, is a milestone in the history of anesthesiology.
Muscle relaxants in accordance with the mechanism into two categories: depolarizing muscular relaxants and non-depolarizing muscular relaxants two. At present, clinical use for more than ten kinds of muscle relaxants. In recent years, muscle relaxants steady growth in the amount of drugs used in hospitals, and the growth trend will continue.
Muscle relaxant listed in our initial stages of pharmaceutical production technology is not mature enough as a result the number of hospital medication fluctuations. In 2000, the muscle relaxant Although the number of hospital medication record levels, but the amount of medication is not prominent. Then, with various pharmaceutical companies on Pharmacy Technology upgrading and the development of similar drugs, muscle relaxant drugs used in hospitals has significantly improved the amount gradually. Although the number of hospital administration in 2007 than in 2000 decreased by 44.2%, but the drug increased the amount of 72.8%, and growth continues to this day, believe that the future amount of muscle relaxant drugs there will be further improved.
2008 the first half of the amount in the sample share the hospital administration's top four were muscle relaxants: vecuronium, atracurium besylate salt, rocuronium, eperisone hydrochloride.
Which vecuronium, with its side effects, such as repeated drug-free accumulation feature has been the muscle relaxant of the more popular varieties. 2000 to 2005, the amount of share of hospital medication generic drug for more than 43% of the total share in 2001, the amount of drugs is achieved 60.3% share. Later, with the involvement of the domestic pharmaceutical companies, and rocuronium new drugs such as the rise of the drug vecuronium share began to decline, but 2006,2007 are more than 36% share in two years, always in such products leader.
Rocuronium as a new generation of muscle relaxants, since 2000 has been listed in China, with its rapid onset, longer duration, security, etc, recognized by the majority of patients in each hospital market drugs volume has a relatively high growth. Enter the Chinese market in 2000 year, the amount of hospital medication only share the same amount of drug to 0.7%, but in 2007, the amount of its share of the hospital administration has been as high as 19%, showing good growth. The product is still great potential for the future.
Organon is the first to enter China's market muscle relaxants one of the foreign pharmaceutical companies, the company with its vecuronium, rocuronium and other drugs, technological advantages, has maintained a dominant market position. 2005 to 2007, Organon amount of drugs used in hospitals, accounting for 32% share.
2008 first half, the amount of muscle relaxant market share according to rank the top three are living: Organon (32.5% share of the hospital administration), HRH Medicine (Hospitals share of 25.6%), Xian Ju Pharmaceutical (12.9% share of the hospital administration).
Looking at the domestic market has been one of the last 3 years, muscle relaxants top two market share in Beijing and Shanghai city, the two cities share of total consumption were more than 40%. Tianjin, Chongqing, Hangzhou, Chengdu and other cities despite the limited amount of medication, but also showed good development potential, the next concern. First half of 2008, muscle relaxants drug top five cities are: Shanghai (20.8%), Beijing (17.2%), Chongqing (8.5%), Tianjin (8.4%), Guangzhou (5.8%).
Muscle relaxant in the development of our country is now in the golden period of the hospital market, although still dominated by foreign products, but with the expiration of administrative protection of pharmaceuticals foreign and domestic Generic Goods market, relying on price advantage, muscle relaxant drugs will usher in a new round of Sell Peak.
