subject: Lyme Disease Identification [print this page] In 2010, the presence of Lyme in the body no longer has to be a guessing game.
1975 was the first recognition of the condition in Lyme, CT. The problem of bringing Lyme disease to resolution for those afflicted with the symptoms,has been to accurately identify the disease. However, the history of the disease goes back to 1883 as you can see by the graph below provided by Brown University relying on information provided in part by Douglas Dodge (See references below). Since the formal recognition and naming of the disease, Lyme has spread and continues to do so at an alarming rate.
Timeline of important events in the history of Lyme Disease
1883 - The first recorded case of Lyme Disease is described by Alfred Buchwald. He described it as a degenerative skin disorder now known as ACA (acrodermatitis chronica atorphicans).
1909 - Arvid Afzelius presents his research on expanding ring like lesion (erythema migrans) associated with what would become known as Lyme Disease.
1921 - Arvid Afzelius publishes his work and speculates on the origin of the disease as the Ixodes Scapularis tick and connects the disease with joint problems.
1922 - The disease is found to be associated with neurological problems.
1930 - Psychiatric problems are found to also be caused by the disease.
1934 - Benign lymphocytomas are associated with the appearance of EM or ACA. Arthritic symptoms are reported in connection with the disease.
1970 - Rudolph Scrimenti, professor of dermatology publishes reports of the rash.
1975 - Allen C. Steere, Yale, investigates a group of rashes and swollen joints in Lyme, Connecticut. Scrimenti publishes about his treatment of the rash with penicillin.
1976 - A clustering of cases of the disease is reported in a Naval Medical Hospital in Connecticut.
1977 - Steere et. Al misdiagnoses Lyme Disease as juvenile rheumatoid arthritis and names the condition Lyme Arthritis.
1982 - The etiological agent of the disease, Borrelia burgdorferi, is discovered by Dr. Willy Burgdorfer.
1983 - Treatment of Lyme disease with oral and intravenous antibiotics begins and clinicians define the three stages of Lyme Disease.
1986 - Skeptics denounce the existence of Lyme Disease.
1988 - Lyme Disease Foundation (LDF) Founded.
1997 - Borrelia burgdorferi genome sequenced by TIGR.
1999 - Smith Kline Beecham receive FDA approval and place LYMErix vaccine on the market.
2002 - LYMErix vaccine removed from market.
Blood test provided the first means of identifying Lyme Disease. Unfortunately, a large percentage of the results generated from this method were found to be inaccurate.
2010 - Of most recent importance is the following
According to an article published March 30th, 2010 entitled Connecticut Pathologist Debuts Lyme Disease Test Based on Nested PCR, DNA Sequencing, by Kirell Lakhman, "A scientist in Connecticut has launched a test that uses nested PCR and DNA sequencing to detect the presence of Borrelia burgdorferi, the bacterium that causes Lyme disease.
Prior to the onset of the tick season of 2010, the test, referred to as LoTemp, is being made available. Other PCR-based tests for the indication exist, "{b}ut this is the first one using nested PCR for detection and DNA sequencing to validate the molecular diagnosis in clinical laboratory medicine."
The assay, developed by Sin Hang Lee, a pathologist at Milford Hospital in Milford, Conn., can be used before patients undergo traditional serology testing for the bug. In the Unied States, it is suspected that more than 30,0000 are infected with spirochete B. burgdorferi each year.
The test uses nested PCR to detect genomic DNA of B. burgdorferi in blood, and uses Sanger-based DNA sequencing and diagnostic signature sequences found in GenBank to validate the result, according to the statement. (The polymerase chain reaction (PCR) is a scientific technique in molecular biology to amplify a single or a few copies of a piece of DNA across several orders of magnitude, generating thousands to millions of copies of a particular DNA sequence.)
Up to 75 percent of patients with "acute-phase Lyme disease are negative for the characteristic antibodies, but in fact the percentage is higher," the statement said. However, a negative result does not rule out the presence of the bacteria because spirochetlemia, or the presence of spirochetes in the blood, "is transient and its time points in Lyme {disease} vary from patient to patient."
"It is the marriage of {nested PCR and DNA sequencing} that minimizes false-negatives to the lowest possible and eliminates false-positives known to be associated with other Lyme disease DNA tests," it said."
The point is that the approach to Lyme disease detection and resolution has relied on traditional allopathic approaches. However, Lyme Disease has a distinct energetic signature and a process we call Bio-communications Diagnostics is designed to detect and measure that energetic signature response. A computer generated stressor signal is send to the body during a Bio-Communications Diagnostic session. In response to the stressor signal, an energetic signature signal is received back. This response provides an energetic measurement showing the presence of Lyme related bacterium associated with the Lyme Spirochetes. From this response, the presence of Lyme can be confirmed and the Lyme bacterial load level in the body can be determined.
2010, the good news is that the presence of Lyme in the body no longer has to be a guessing game, nor does resolution of the disease have to include antibiotics.
References:
Brown University Lyme Disease History - http://www.brown.edu/Courses/Bio_160/Projects2005/lyme_disease/references.htm
