subject: Agmatine - China White Stone Texture - Wall Stone Texture [print this page]

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Clinical significance
Clinical significance

Treatment with exogenous agmatine exerts neuroprotective effects in animal models of ischemia and neurotrauma.

History

The term "agmatine" was coined in 1910 by Albrecht Kossel, the German scientist who first identified the substance in herring sperm.

See also

Agmatine deiminase

References

^ Kossel, Albrecht 1910. ber das Agmatin. Zeitschrift fr Physiologische Chemie 66: 257-261

Jae-Hwan Kim, et al. Agmatine reduces infarct area in a mouse model of transient focal cerebral ischemia and protects cultured neurons from ischemia-like injury. Experimental Neurology. 189 (2004) 122 130

Sa-Hyun Kim. Regulation of subventricular zone stem cell proliferation and differentiation by agmatine. Graduate School, Yonsei University. (2006) article

Central Sensitization: The endogenous NMDA antagonist and NOS inhibitor Agmatine inhibits spinal long term potentiation (G. Wilcox, A. Fiska, F. Haugan, F. Svendsen, L. Rygh, A. Tjolsen and K. Hole. American Pain Society. Published by Elsevier Science. 2004)

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Amino acid metabolism metabolic intermediates

Kcetyl-CoA

lysine

Saccharopine Allysine -Aminoadipic acid -Aminoadipate Glutaryl-CoA Glutaconyl-CoA Crotonyl-CoA -Hydroxybutyryl-CoA

leucine

-Ketoisocaproic acid Isovaleryl-CoA 3-Methylcrotonyl-CoA 3-Methylglutaconyl-CoA HMG-CoA

tryptophanlanine

N'-Formylkynurenine Kynurenine Anthranilic acid 3-Hydroxykynurenine 3-Hydroxyanthranilic acid 2-Amino-3-carboxymuconic semialdehyde 2-Aminomuconic semialdehyde 2-Aminomuconic acid Glutaryl-CoA

G

Gyruvateitrate

glycineerine

3-Phosphoglyceric acid

glycinereatine: Glycocyamine Phosphocreatine Creatinine

Glutamate

-ketoglutarate

histidine

Urocanic acid Imidazol-4-one-5-propionic acid Formiminoglutamic acid Glutamate-1-semialdehyde

proline

1-Pyrroline-5-carboxylic acid

arginine

Ornithine Putrescine Agmatine

other

cysteine+glutamatelutathione: -Glutamylcysteine

Gropionyl-CoA

succinyl-CoA

valine

-Ketoisovaleric acid Isobutyryl-CoA Methacrylyl-CoA 3-Hydroxyisobutyryl-CoA 3-Hydroxyisobutyric acid 2-Methyl-3-oxopropanoic acid

isoleucine

2,3-Dihydroxy-3-methylpentanoic acid 2-Methylbutyryl-CoA Tiglyl-CoA 2-Methylacetoacetyl-CoA

methionine

generation of homocysteine: S-Adenosyl methionine S-Adenosyl-L-homocysteine Homocysteine

conversion to cysteine: Cystathionine alpha-Ketobutyric acid+Cysteine

threonine

-Ketobutyric acid

propionyl-CoA

Methylmalonyl-CoA

Gumarate

phenylalanineyrosine

4-Hydroxyphenylpyruvic acid Homogentisic acid 4-Maleylacetoacetate

Gxaloacetate

see urea cycle

Other

Cysteine metabolism

Cysteine sulfinic acid

see also enzymes, disorders

This biochemistry article is a stub. You can help Wikipedia by expanding it.

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Categories: Amines | Guanidines | Metabolism | Biochemistry stubs

by: gaga

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