subject: Pharmaceutical Excipients Time Due To Several Adverse Reactions - Pharmaceutical Excipients - [print this page] With the new formulation and drug delivery systems development, Pharmaceutical Excipients Wider and wider application. Inertia in people's thinking, the medicine Accessories To be non-activity, so a medication appears Adverse reactions People are often attributed to the active ingredient. In fact, the accessories is not inert, a considerable number of clinical drug adverse reaction caused by excipients.
Benzyl alcohol caused heavy damage of gluteal muscle contracture
Benzyl alcohol as a drug solvent, preservative (0.5% - 1.0%) and local analgesia (1% - 4%), adverse reactions, including hemolysis, hypotension, local stimulation.
Benzyl alcohol can be combined with the red cell membrane, resulting in hemolysis. Is also the main cause of gluteal muscle contracture. 2% benzyl alcohol penicillin potassium salt of the solvent used for the purpose of relieving pain when injected. Infant gluteal injection of this product on the muscle tissue irritation and severe chemical injury, resulting in gluteal muscle contracture, and, once the disease will not be reversed, to cause serious harm to physical and mental development of children.
Ethanol injection solvent, lodging, Ethanol as solvent used in a variety of injection of insoluble drugs, such as prostaglandin E2 injection, hydrocortisone injection, Vitamin A combined injection of ascorbic acid, etc., intramuscular or subcutaneous injection may be great irritation. First produce a burning sensation at the injection site, intense pain, followed by local anesthesia: If accidentally injected close to the nerve, can cause neurological damage.
Polysorbate 80 caused by allergies occur
Polysorbate 80 non-ionic surfactants, commonly used for poorly soluble drugs, solvents, emulsifiers, and sometimes allergic reactions occur.
Polysorbate 80 as the intravenous anesthetic etomidate, antineoplastic agents etoposide, docetaxel solvent, allergic response rate of 5% - 40%. Manifested as hypotension, bronchospasm, panel flushing, rash, difficulty breathing, tachycardia and fever, chills, pre-service antihistamines, steroid hormone class medicine to ease.
Lactose intolerance by taking easy to distension
Lactose for tablets, capsules, powder diluent, sweeteners, also used in aerosol inhalation powder diluent. On lactose intolerance are taking preparations containing lactose excipients, can produce abdominal distension, abdominal pain, diarrhea and other serious adverse reactions.
Lactose as the diluent dry powder inhaled aerosol, the content of small lung can be quickly absorbed by the urinary excretion, even for those who do not tolerate that they are safe; oral tablets lactose content is high, for intolerance who is going to be some risk.
Long-term high-dose use of preservatives to be cautious
Benzalkonium chloride benzalkonium chloride is a cationic surfactant, used as a drug preservative, solubilizer, absorption enhancer. Found only low concentrations it causes allergic reactions, local mucosal damage. As a preservative in many solution-based aerosols, long-term use can lead to benzalkonium chloride accumulation in the airway, resulting in small bronchi, cough, burning sensation, facial flushing, itching. Because of this response is dose dependent and cumulative nature, but also easy to cover up the role of active components, so rarely anti-asthma agents attributed to adverse reactions such as bronchial narrow benzalkonium chloride.
Allergic to report the majority of artificial coloring agents
Coloring agent into the natural coloring agents and artificial colorants. Artificial colorants are often reported allergic reactions, such as neutral red, indigo blue, quinoline yellow, gentian violet and other reports of contact dermatitis; sunset yellow gastrointestinal intolerance, can produce abdominal pain, vomiting, dyspepsia; red Red ringworm can cause photosensitivity dermatitis, erythroderma, scaling and other skin diseases, has banned the use of topical agents, because of its well Cancer , Which also limits the use of some oral liquid.
