subject: What Are The Relation Between Fragile Bones,(Osteoporosis) And Age Factor ? [print this page] What Are The Relation Between Fragile Bones,(Osteoporosis) And Age Factor ?
For better understanding of this big question; we should know that: Fragile bones, or brittle bones, ( Osteoporosis) is a multifactorial, age- related metabolic disease as i explain in http://fragilebone.blogspot.com/. There are many causes with age; as underweight,family history,previous fracture following a low-level trauma, especially after age 50. Also, sex hormone deficiency,Excessive alcohol,low dietary intake or absorption of calcium and vitamin D, poor lifestyle or immobility,medications as glucocorticoid medications such as (prednisolone, excess thyroid hormone replacement, the blood thinner heparin, certain anti-epilepsy medications such as phenytoin and so on),certain diseases can affect bone, such as endocrine disorders as (hyperthyroidism, hyperparathyroidism, Cushing's disease, and so on) and certain forms of arthritis,as rheumatoid arthritis. For better understanding the Age factor, we should understand some of bone structure and the process of bone developments. There are two major types of bone cells( Osteoblasts) and (Osteoclasts). The first type, Osteoblasts are responsible for bone formation and bone regeneration and this type of cells are originated from( Mesenchymal) cells which also, originated from( Mesenchymal Stem Cells). This Stem Cells are age related; and by increasing of age some sort of delaying and self-renewal deficiency appears with Osteoblasts, function. This result in decrease in bone mass formation and delaying in the process of regenration . Also it affects old age, men or women and leads to type 2, Osteoporosis or age related Osteoporosis,witch characterized by high risk of fractures especially in hip bones . The second type,of cells called Osteoclasts, are responsible for bone resorption. Osteoclasts, are originated from bone marrow producing cells as( Monocyte and Macrophage) . The decrease in Osteoclasts, leads to high increase in bone turnover .That leads to vertebral fractures especially, in lumber vertebrae also, in the head of femur . This, increase in bone turnover; may assets in Postmenopausal Osteoporosis, or type l, Osteoporosis,. "Also sex hormones deficiency (Estrogen) is the main cause of postmenopausal osteoporosis, in old women". Finaly, Type 2, Osteoporosis, (age factor related) are thought, result from deregulated bone remodeling during age. Normal bone remodeling need a strong balance between bone resorption by Osteoclasts and bone formation by Oseoblasts.
