subject: Clinical Trial Patient Recruitment: Accelerate Enrollment, Increase Retention and Reduce Costs [print this page] Clinical Trial Patient Recruitment: Accelerate Enrollment, Increase Retention and Reduce Costs
Clinical trial costs are skyrocketing amidst patient shortages, fewer drug approvals and limited growth in the number of available clinical investigators. At the same time, companies face stringent demands for more safety data and patient recruitment stands as a pivotal roadblock. As pressure mounts and competition for patients intensifies, superior trial teams build resilient strategies for attracting and retaining patients, and their efforts are backed by sufficient resources.
Accelerate enrollment and expand your clinical capabilities with our detailed benchmarks and best practices from more than 80 companies across the life sciences. Use this report to eliminate barriers to patient recruitment and ensure trial completion:
Master trial recruitment: Explore 16 patient recruitment activities and track the effectiveness of each strategy. Learn how trial protocol can stimulate patient participation. Train site staff and investigators to emphasize recruitment.
Motivate patients to enroll: Learn how to think like a patient by mastering eight enrollment motivators including both tangible and emotional draws. Effectiveness ratings for each motivator will guide your strategy as you mine patient demographics and market research to bolster recruitment.
Integrate recruitment into formal trial structure and process: Resolve disagreements quickly by determining patient recruitment ownership and strengthening strategic partnerships with vendors. Consider using the
expertise of a patient recruitment specialist.
Budget for patient recruitment: Are you spending enough on patient recruitment? Win increased funding with detailed spending benchmarks (including recruitment as a percentage of the total trial budget), site-specific budget data, and information for 10 therapeutic areas and medical devices.
TABLE OF CONTENTS :
13 Executive Summary
17 Study Methodology
18 Study Definitions
19 Profiled Companies
20 Patient Recruitment: Five Key Findings and Recommendations
27 Supporting Patient Recruitment with Increased Budgets
79 Integrating CRO Outsourcing with Internal Structure
80 Patient Recruitment Structure
84 Using a CRO to Assist with Patient Recruitment
88 Best Practices in CRO Contracting
95 Methods and Activities to Improve Patient Recruitment
97 Site and Patient Demographic Evaluation
107 Site Development
115 Mass Media Marketing
123 External Patient Recruitment Activities
131 Patient Motivators and Patient Retention
132 Patient Motivators
142 Patient Retention
155 Company Profiles
156 Oncology Trials
170 Type 2 Diabetes Trials
174 Obesity Trials
176 Cardiology and Thrombosis Trials
180 CNS/Neurology Trials
186 Mental Health Trials
190 Hematology Trials
192 Infectious Disease Trials
196 Pain Trials
198 Rheumatology Trials
200 Respiratory Trials
202 Medical Technology Trials
204 Consumer Products Trials
206 Other Trials
KEY METRICS
The five chapters in Clinical Trial Patient Recruitment include benchmarks that detail patient recruitment spending, structure, and activities, as well as data for patient enrollment motivators, recruitment tools and retention strategies.
Chapter 1: Supporting Patient Recruitment with Increased Budgets
(52 data charts)
Patient recruitment budget data for sponsors, sites and CROs broken out by trial phase (Phase 1, 2, 3a and 3b, and 4):
Percentage of clinical trial budget dedicated to patient recruitment
Dedicated patient recruitment budgets (trials and sites)
Total trial budgets per phase at trial level and site-specific level
Patient recruitment budgets per patient enrolled
Patient recruitment spending data broken out by therapeutic area:
Cardiovascular
Central Nervous System/Neurology
Type 2 Diabetes
Hematology
Infectious Disease
Inflammation
Mental Health
Oncology
Pain
Urology
Medical Device/Diagnostic
Chapter 2: Integrating CRO Outsourcing with Internal Structure
(5 data charts)
Prominence of recruiting outsourcing, including reasons sponsors contract with vendors for patient recruitment
Popularity of dedicated patient recruitment groups
Efforts to integrate patient recruitment into trial protocol design
Chapter 3: Methods and Activities to Improve Patient Recruitment
(31 data charts)
Data (including effectiveness rankings) for 16 patient recruitment activities:
Evaluating site and investigators
Conducting patient demographic/population research
Working with advocacy groups
Organizing health fairs and community outreach
Training site staff/investigators on patient recruitment
Developing site support materials
Using Medical Science Liaisons (MSLs)
Managing a call center
Contacting patient referrals
Managing mass media marketing:
Radio
Newspaper/print
Television
Web-based marketing
Chapter 4: Patient Motivators and Patient Retention
(21 data charts)
Effectiveness by phase for the following Patient Motivators:
Prospect of improved treatment
Convenience of sites
Prospect of free medication/treatment
Number/frequency of visits
Short trial duration
Transportation compensation
Monetary compensation
Non-monetary incentives
Percentage of companies using Patient Retention strategies, by phase and company type:
Visit reminders by email
Visit reminders by text message
Print/paper patient support materials
Online patient support materials
Treatment follow-up by phone
Follow-up by web/email
Transportation assistance
Patient visits
Caregive support
Chapter 5: Company Profiles
(54 data charts)
Each profile contains the following information:
Patient Recruitment Profile
Trial information
Therapeutic area
Number of patients enrolled
Trial status
Company Information
Company type
Region
Patient Recruitment Spending
Presence/absence of dedicated budget
Total trial budget
Patient Recruitment Timeline
Targeted enrollment vs. actual enrollment
Months behind or ahead of schedule
Patient Recruitment Tactics
Patient recruitment activity
Company performing task (e.g., sponsor, CRO, other vendor)
